Tremor-correlated cortical activity in essential tremor
Tremor-correlated cortical activity in essential tremor
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DOI：
10.1016/s0140-6736(00)04044-7
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发表时间：
2001-02-17
期刊：
影响因子：
168.9
通讯作者：
Lücking, CH
中科院分区：
文献类型：
--
作者：
Hellwig, B;Häussler, S;Lücking, CH
背景在帕金森病静止性震颤患者中，对侧感觉运动皮层的震颤相关活动已被脑磁图（MEG）和脑电图（EEG）研究。在特发性震颤中，MEG未能检测到皮质受累。本研究的目的是探讨脑电图记录是否可以揭示震颤相关的皮质活动的患者原发性震颤或增强的生理性震颤。(MEG)方法7例原发性震颤患者和3例增强型生理性震颤患者参加了研究。单侧姿势性震颤由右侧或左侧的手腕伸展激活。肌电图（EMG）信号所产生的腕伸肌和屈肌，并同时记录高分辨率的脑电图。校正震颤EMG和EEG的时间序列之间的一致性estimated.Findings在五个9手臂原发性震颤，我们发现非常显着的一致性震颤EMG和EEG之间的震颤频率。等相干图显示了头皮上显著的相干性地形图，最大的相干性位于对侧感觉运动皮层。在增强的生理性震颤的患者中，我们无法检测到一致的显着corticomuscoherencies在震颤frequency.Interpretation使用同步EEG-EMG记录，我们发现，显着corticomuscoherencies在震颤频率可以发现在特发性震颤。这一发现与最近基于MEG记录的研究形成对比。结果表明，感觉运动皮层参与特发性震颤的产生。其方式与先前在帕金森病静止性震颤中所示的方式类似。
Background In patients with parkinsonian resting tremor, tremor-correlated activity in the contralateral sensorimotor cortex has been studied by both magnetoencephalography (MEG) and electroencephalography (EEG). In essential tremor, MEG failed to detect cortical involvement. The objective of this study was to investigate whether EEG recording can reveal tremor-correlated cortical activity in patients with essential tremor or enhanced physiological tremor. (MEG) tremor.Methods Seven patients with essential tremor and three patients with enhanced physiological tremor participated in the study. Unilateral postural tremor was activated by wrist extension on the right or on the left side. Electromyography (EMG) signals arising from the wrist extensor and flexor muscles, and a high-resolution EEG were recorded simultaneously. Coherences between the time series of the rectified tremor EMG and the EEG were estimated.Findings In five of nine arms with essential tremor, we found highly significant coherences at the tremor frequency between the tremor EMG and the EEG. Isocoherence maps illustrating the topography of significant coherences over the scalp showed that the maximum coherences were located over the contralateral sensorimotor cortex. In the patients with enhanced physiological tremor, we were unable to detect consistent significant corticomuscular coherences at the tremor frequency.Interpretation Using simultaneous EEG-EMG recordings, we showed that significant corticomuscular coherences at the tremor frequency can be found in essential tremor. This finding contrasts with a recent study based on MEG recordings. The results suggest that the sensorimotor cortex is involved in the generation of essential tremor. in a similar way to that previously shown in parkinsonian resting tremor.