The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns
The effects of probiotics on feeding tolerance, bowel habits, and gastrointestinal motility in preterm newborns
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DOI：
10.1016/j.jpeds.2007.11.005
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发表时间：
2008-06-01
影响因子：
5.1
通讯作者：
Francavilla, Ruggiero
中科院分区：
文献类型：
--
作者：
Indrio, Flavia;Riezzo, Giuseppe;Francavilla, Ruggiero
目的探讨益生菌对健康配方奶粉喂养早产儿喂养耐受性和胃肠动力的影响。10例为纯母乳喂养，其余20人以双盲方式随机分配接受罗伊氏乳杆菌ATCC 55730（每天1 × 10（8）个菌落形成单位的剂量）或安慰剂治疗30天。记录饮食干预前后胃肠道功能的临床症状（反流、呕吐、伤心哭泣和排空）和生理变量（胃电活动和排空）。接受益生菌的新生儿与接受安慰剂的新生儿相比，其反流和平均每日哭泣时间显着减少，排便次数也更多。两组新生儿的胃排空率显著增加，空腹胃窦面积显著减少。结论：我们的研究结果表明，乳杆菌在新生儿中的作用是有益的。reuteri补充剂改善配方奶粉喂养的早产儿的喂养耐受性和肠道功能。
Objective To investigate the effect of dietary supplementation with a probiotic on feeding tolerance and gastrointestinal motility in healthy formula-fed preterm infants.Study design Thirty preterm newborns were enrolled; 10 were exclusively breast-fed, and the remaining 20 were randomly assigned in a double-blind manner to receive either Lactobacillus reuteri ATCC 55730 (at dose of 1 x 10(8) colony forming units it day) or placebo for 30 days. Clinical symptoms of gastrointestinal function (regurgitation, vomiting, inconsolable crying, and evacuation) and physiological variables (gastric electrical activity and emptying) were recorded before and after the dietary intervention.Results Body weight gains per day were similar for the 3 groups, and no adverse events were recorded. Newborns receiving probiotics showed a significant decrease in regurgitation and mean daily crying time and a larger number of stools compared with those given placebo. Gastric emptying rate was significantly increased, and fasting antral area was significantly reduced in both the newborns receiving L. reuteri and breast-fed newborns compared with placebo.Conclusions Our results suggest a useful role for L. reuteri supplementation in improving feeding tolerance and gut function in formula-fed preterm newborns.