The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk
The role of C-reactive protein polymorphisms in inflammation and cardiovascular risk
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DOI：
10.1007/s11883-009-0020-z
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发表时间：
2009-03-01
影响因子：
5.8
通讯作者：
Szalai, Alexander J.
中科院分区：
文献类型：
--
作者：
Hage, Fadi G.;Szalai, Alexander J.
在过去的十年中，对C反应蛋白（CRP）及其在表面健康个体中的血清水平与心血管疾病风险之间的关联的兴趣激增。最近的研究表明，CRP水平的个体间差异不仅反映了环境因素，而且也是CRP基因本身遗传变异的结果。CRP基因变异与CRP血清水平和心血管疾病风险之间的关系对于建立CRP基因谱作为临床风险预测工具以及帮助检测CRP与血管疾病之间的因果关系非常重要。本文综述了CRP基因多态性与炎症和心血管风险关系的最新研究。
Interest in C-reactive protein (CRP) and the association of its serum level in apparently healthy individuals to their cardiovascular disease risk has soared over the past decade. Recent studies have shown that the interindividual variations in CRP levels not only reflect environmental cues but are also a consequence of the genetic variation in the CRP gene itself. The importance of the relationship of CRP gene variants to CRP serum level and cardiovascular disease risk is important to establish CRP gene profiling as a clinical risk prediction tool and also to help test the cause-effect relationship between CRP and vascular disease. This article reviews recent studies that address the relationship of CRP gene polymorphisms to inflammation and cardiovascular risk.