The role of the Nod-like receptor family in trophoblast innate immune responses
The role of the Nod-like receptor family in trophoblast innate immune responses
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DOI：
10.1016/j.jri.2010.12.003
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发表时间：
2011-03-01
影响因子：
3.4
通讯作者：
Abrahams, Vikki M.
中科院分区：
文献类型：
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作者：
Abrahams, Vikki M.
宫内感染与早产等妊娠并发症有很强的临床相关性。胎盘起着主动屏障的作用，滋养细胞通过模式识别受体识别微生物，如功能良好的Toll样受体，以对母胎界面上的病原体做出反应。因此，胎盘对感染诱因的反应低效或过度活跃，都可能对妊娠结局产生重大影响。最近发现胎盘表达一个新发现的模式识别受体家族，即基于细胞质的NOD样受体(NLRs)。由于其有限的定位，NLR作为细胞内受体发挥作用，对感染成分做出反应，这些感染成分进入细胞质隔间。因此，NLRs可能为滋养细胞提供一种识别系统，该识别系统可能在胎盘对微生物或其细胞壁成分的反应中至关重要，这些微生物或其细胞壁成分已进入细胞内空间，或已逃避TLRs的识别。这篇综述将讨论目前已知的NOD蛋白、NALP蛋白和母胎交界处的炎症体的作用，以及它们在感染相关妊娠并发症(如早产)中的潜在作用。随着我们更多地了解它们在母胎界面上的功能，我们将更好地了解它们在正常妊娠中的功能，以及它们在感染和炎症相关妊娠并发症的发病机制中的作用。(C)2011爱思唯尔爱尔兰有限公司。保留所有权利。
There is a strong clinical association between intrauterine infections and pregnancy complications, such as preterm labor. The placenta functions as an active barrier whereby the trophoblast recognizes microbes through pattern recognition receptors, such as the well characterized Toll-like receptors, in order to respond to pathogens at the maternal-fetal interface. Consequently, either an inefficient or overactive placental response to an infectious trigger, may have a significant impact on pregnancy outcome. Recently the placenta has been shown to express a newly identified family of pattern recognition receptors, the cytoplasmic-based Nod-like receptors (NLRs). As a result of their restricted localization, NLRs function as intracellular receptors that respond to infectious components, which have gained access to the cytoplasmic compartment. Thus, NLRs may provide the trophoblast with a recognition system that may be critical in placental responses to microorganisms or their cell wall components that have gained access to the cell's intracellular space, or that have evaded recognition by the TLRs. This review will discuss what is currently known about the role of NOD proteins, NALP proteins, and the inflammasome at the maternal-fetal interface, and their potential role in infection-associated pregnancy complications, like preterm labor. As we learn more about their function at the maternal-fetal interface, we will have a better understanding of their function in normal pregnancy and their potential to contribute to the pathogenesis of infection- and inflammation-associated pregnancy complications. (C) 2011 Elsevier Ireland Ltd. All rights reserved.