Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans
Blue light exposure decreases systolic blood pressure, arterial stiffness, and improves endothelial function in humans
复制标题
蓝光照射可降低人体收缩压、动脉僵硬度并改善内皮功能
DOI：
10.1177/2047487318800072
复制
发表时间：
2018
影响因子：
8.3
通讯作者：
C. Heiss
中科院分区：
文献类型：
--
作者：
M. Stern;Melanie Broja;R. Sansone;Michael Gröne;Simon S. Skene;J. Liebmann;C. Suschek;M. Born;M. Kelm;C. Heiss
目的以前的研究表明，紫外线可以导致皮肤释放一氧化氮，降低血压。与可见光相反，局部应用紫外线具有致癌风险。在这里，我们研究了全身暴露于可见蓝光是否也可以降低血压并增加健康受试者的内皮功能。方法14名健康男性受试者随机交叉暴露于单色蓝光或带滤光片的蓝光（对照光）中30 min。我们测量了血压（主要终点），心率，前臂血管阻力，前臂血流量，内皮功能（血流介导的扩张），脉搏波速度和血浆一氧化氮，亚硝酸盐和亚硝基化合物（次要终点）在暴露期间和暴露后2小时。结果与对照组相比，蓝光暴露显著降低收缩压和增加心率。与此同时，蓝光显著增加前臂血流量，流量介导的扩张，循环一氧化氮和亚硝基化合物，而它降低前臂血管阻力和脉搏波速度。结论可见蓝光全身照射可通过光不稳定的一氧化氮代谢产物释放到循环血液中改善血压、内皮功能和动脉僵硬度。
Aims Previous studies have shown that ultraviolet light can lead to the release of nitric oxide from the skin and decrease blood pressure. In contrast to visible light the local application of ultraviolet light bears a cancerogenic risk. Here, we investigated whether whole body exposure to visible blue light can also decrease blood pressure and increase endothelial function in healthy subjects. Methods In a randomised crossover study, 14 healthy male subjects were exposed on 2 days to monochromatic blue light or blue light with a filter foil (control light) over 30 minutes. We measured blood pressure (primary endpoint), heart rate, forearm vascular resistance, forearm blood flow, endothelial function (flow-mediated dilation), pulse wave velocity and plasma nitric oxide species, nitrite and nitroso compounds (secondary endpoints) during and up to 2 hours after exposure. Results Blue light exposure significantly decreased systolic blood pressure and increased heart rate as compared to control. In parallel, blue light significantly increased forearm blood flow, flow-mediated dilation, circulating nitric oxide species and nitroso compounds while it decreased forearm vascular resistance and pulse wave velocity. Conclusion Whole body irradiation with visible blue light at real world doses improves blood pressure, endothelial function and arterial stiffness by nitric oxide released from photolabile intracutanous nitric oxide metabolites into circulating blood.
DOI：
10.1016/0027-5107(91)90121-4
发表时间：
1991
期刊：
Mutation research
影响因子：
--
作者：
J. G. Peak;M. Peak
通讯作者：
J. G. Peak;M. Peak
影响因子：
7.4
作者：
Oplaender, Christian;Deck, Annika;Suschek, Christoph V.
通讯作者：
Suschek, Christoph V.
影响因子：
158.5
作者：
Stampfer, MJ;Hu, FB;Willett, WC
通讯作者：
Willett, WC