Quality of Life and Symptoms in Pediatric Brain Tumor Survivors A Systematic Review
Quality of Life and Symptoms in Pediatric Brain Tumor Survivors A Systematic Review
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DOI：
10.1177/1043454213520191
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发表时间：
2014-03-01
影响因子：
1.7
通讯作者：
McCarthy, Patricia
中科院分区：
文献类型：
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作者：
Macartney, Gail;Harrison, Margaret B.;McCarthy, Patricia
对于20岁以下儿童和青少年完成儿科脑肿瘤治疗后的生活质量知之甚少。本系统综述旨在（a）描述儿童脑肿瘤幸存者的健康相关生活质量（HRQL）结局，（B）确定用于测量HRQL的工具，（c）确定症状与HRQL之间的关系。使用系统检索和综述方法，检索的数据库包括CINAHL、Medline、Embase和PsycInfo。没有使用日期限制。检索结果共得到485篇文献，其中16篇符合纳入标准。与健康的同龄人相比，儿童脑肿瘤幸存者在HRQL的生理、心理、社会和认知领域的大多数指标上表现更差。与其他癌症患者相比，幸存者在儿科生活质量量表（PedsQL）社会功能量表上的得分明显较低，脑肿瘤幸存者的父母报告其子女的PedsQL社会和总功能评分较低。与HRQL降低相关的其他变量包括下丘脑肿瘤累及程度、骨质减少、需要特殊教育、诊断时年龄较大、治疗后超过1年和放射治疗。在这些研究中，与其他癌症幸存者或健康同龄人相比，儿童脑肿瘤幸存者在几个HRQL领域表现更差。只有3项研究探讨了儿童脑肿瘤幸存者的症状（包括疼痛或疲劳）与HRQL之间的关系。症状和HRQL之间的关系没有得到很好的阐明。需要更多的研究来探索儿童脑肿瘤幸存者的多维症状体验和HRQL结局。
Little is known about the quality of life of children and youth under the age of 20 who have completed treatment for a pediatric brain tumor. This systematic review was conducted to (a) describe the health-related quality of life (HRQL) outcomes in pediatric brain tumor survivors, (b) identify instruments used to measure HRQL, and (c) determine the relationship between symptoms and HRQL. Using a systematic search and review methodology, databases searched included CINAHL, Medline, Embase, and PsycInfo. No date restrictions were used. Search results elicited 485 articles, of which16 met the inclusion criteria. Compared with their healthy peers, pediatric brain tumor survivors did worse on most measures of physical, psychosocial, social, and cognitive domains of HRQL. Compared with other cancer patients, survivors scored themselves significantly lower on the Pediatric Quality of Life Inventory (PedsQL) social functioning scale, and parents of brain tumor survivors reported lower PedsQL social and total functioning scores for their children. Other variables that were associated with decreased HRQL were degree of hypothalamic tumor involvement, osteopenia, need for special education, older age at diagnosis, greater than 1 year since treatment, and radiation treatment. In these studies, pediatric brain tumor survivors fared worse compared with other cancer survivors or healthy peers on several HRQL domains. Only 3 studies explored the relationship between symptoms, including pain or fatigue, and HRQL in pediatric brain tumor survivors. The relationship between symptoms and HRQL was not well elucidated. More research is needed to explore the multidimensional symptom experience and HRQL outcomes in pediatric brain tumor survivors.