ANALYSIS OF THE DEVELOPMENTAL EFFECTS OF A LETHAL MUTATION IN THE HOUSE MOUSE
ANALYSIS OF THE DEVELOPMENTAL EFFECTS OF A LETHAL MUTATION IN THE HOUSE MOUSE
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DOI：
10.1002/jez.1401270206
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发表时间：
1954-01-01
影响因子：
--
通讯作者：
AUERBACH, R
中科院分区：
文献类型：
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作者：
AUERBACH, R
研究了纯合子条件下家鼠显性突变“斑点”的影响。纯合子斑点胚胎在受精后9天半可被识别，在发育第13天开始死亡。在这些胚胎中观察到的畸形包括骨裂、颅裂、神经组织过度生长、神经管管腔异常、脊髓神经节及其衍生物减少或缺失以及尾巴形态异常。在移植实验中研究了斑点纯合子被皮的成色能力。正常小鼠组织在鸡体腔或小鼠眼睛前房生长时会产生色素，而斑点纯合子的相应组织则缺乏这种产生色素的能力。在斑点综合征观察到的异常生产涉及的因果关系进行了讨论。结论是，斑点综合征是基于发育中的胚胎神经嵴和神经管背侧区域的紊乱。这表明，对斑点突变的分析可能为哺乳动物正常的诱导关系及其受遗传因素控制的程度提供一些信息。
The effects of the dominant mutation "Splotch" in homozygous condition were studied in the house mouse. Homozygous Splotch embryos can first be recognized 9 1/2 days after fertilization and die at the beginning of the 13th day of development. The malformations observed in these embryos include rachischisis, cranioschisis, overgrowth of neural tissue, abnormalities in the lumen of the neural tube, reduction or absence of spinal ganglia and their derivatives, and abnormal tail morphology. The pigment-forming capacity of the integument of Splotch homozygotes was studied in transplantation experiments. While normal mouse tissues when grown in the chick coelom or the anterior chamber of mouse eyes will produce pigment, corresponding tissues of Splotch homozygotes lack this capacity to produce pigment. The causal relationships involved in the production of the abnormalities observed in the Splotch syndrome are discussed. It is concluded that the Splotch syndrome is based on a disturbance of the region of the developing embryo which includes the neural crest and the dorsal part of the neural tube. It is suggested that the analysis of the Splotch mutation may furnish some information on normal inductive relationships in mammals and the extent to which these are controlled by genetic factors.