Chemical Constituents from Nicotiana tabacum L. and Their Antifungal Activity
Chemical Constituents from Nicotiana tabacum L. and Their Antifungal Activity
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烟草的化学成分及其抗真菌活性
DOI：
10.1177/1934578x211059578
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发表时间：
2021
影响因子：
1.8
通讯作者：
Kuo Xu
中科院分区：
文献类型：
--
作者：
Chen Yang;Sheng;Lin Ni;Yong;Su;Mao;Kuo Xu
烟草花乙醇水提取物的植物化学研究鉴定了1个新的桉烷型倍半萜（1）和14个已知化合物，包括7个黄酮（2-8）、6个酚酸（9-14）和1个香豆素（15）。1的化学结构是建立在高分辨率电喷雾电离（HRESIMS）和1D和2D NMR分析的基础上，而其他结构通过1D NMR和LC-MS数据进行了解析。对分离得到的化合物进行了抗植物病原菌活性测定。苹果链格孢和灰葡萄孢，浓度为10 µg/mL。 化合物4对苹果腐烂病菌具有较强的抗真菌作用。mali的生长抑制率为47.9 ± 1.2%，而其它的仅显示不显著的活性。
A phytochemical investigation of an aqueous ethyl alcohol (EtOH) extract of the flowers of Nicotiana tabacum L. led to the identification of one new eudesmane-type sesquiterpenoid (1) and 14 known compounds, including 7 flavones (2-8), 6 phenolic acids (9-14), and 1 coumarin (15). The chemical structure of 1 was established on the basis of high-resolution electrospray ionization (HRESIMS) and 1D and 2D NMR analyses, while the other structures were elucidated by 1D NMR and LC–MS data. The antiphytopathogenic activities of all the isolated compounds were tested to determine their antifungal activity against Valsa mali var. mali, Alternaria porri, and Botrytis cinerea at a concentration of 10 µg/mL. Compound 4 exhibited more potent antifungal effects against Valsa mali var. mali with a % growth inhibition of 47.9 ± 1.2%, while the others only showed insignificant activities.