EPIDEMIOLOGIC AND HISTORICAL RELATIONSHIPS AMONG 87 RABIES VIRUS ISOLATES AS DETERMINED BY LIMITED SEQUENCE-ANALYSIS
EPIDEMIOLOGIC AND HISTORICAL RELATIONSHIPS AMONG 87 RABIES VIRUS ISOLATES AS DETERMINED BY LIMITED SEQUENCE-ANALYSIS
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DOI：
10.1093/infdis/166.2.296
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发表时间：
1992-08-01
影响因子：
6.4
通讯作者：
WARNER, CK
中科院分区：
文献类型：
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作者：
SMITH, JS;ORCIARI, LA;WARNER, CK
对狂犬病病毒核蛋白 (N) 基因的 200 bp 区域进行核苷酸序列分析，从亚洲、非洲、欧洲和美洲狂犬病流行地区收集的样本中区分出狂犬病病毒的独特遗传群体。三十年来收集的样本中保留了针对疫情爆发地区确定的核苷酸序列模式。通过保守核苷酸序列的模式确定分离株之间的流行病学关系，并测量来自不同爆发地区的样本之间的序列差异程度。这种方法表明，导致狂犬病传入某个地区的事件的历史重建是可能的。从狂犬病流行病学的更广泛角度来看，欧洲探险和殖民的文化遗产可能还包括人畜共患疾病。
Nucleotide sequence analysis of a 200-bp region of the nucleoprotein (N) gene of rabies virus differentiated unique genetic groups of rabies virus from samples collected in areas where dog rabies is enzootic in Asia, Africa, Europe, and the Americas. Patterns of nucleotide sequence identified for an outbreak area were conserved in samples collected over three decades. Epidemiologic relationships among isolates were determined by patterns of conserved nucleotide sequence, and the degree of sequence divergence between samples from separate outbreak areas were measured. This approach suggested that a historical reconstruction of events leading to the introduction of rabies into an area would be possible. In this broader view of rabies epidemiology, the cultural legacy of European exploration and colonization may have also included zoonotic disease.