A Predictive Study of Coronary Heart Disease: The Western Collaborative Group Study
A Predictive Study of Coronary Heart Disease: The Western Collaborative Group Study
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冠心病的预测研究：西方协作组研究
DOI：
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发表时间：
1964
期刊：
影响因子：
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通讯作者：
N. Werthessen
中科院分区：
文献类型：
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作者：
R. Rosenman;M. Friedman;R. Straus;M. Wurm;R. Kositchek;W. Hahn;N. Werthessen
本研究旨在（1）比较不同参数的“预测”能力及其在未来冠心病（CHD）发病率中的相互关系;（2）通过对前瞻性获得的数据进行回顾性分析，确定冠心病倾向男性的特征。自1960年以来，每年对3，524名年龄在39至59岁之间的男性进行公开行为模式，血脂和凝血，身体测量，社会经济因素，个人习惯和心血管状况的综合研究。在3，411名“健康”男性中，有113人发现了明显的CHD，但在研究时研究人员对此并不知情。冠心病患者的血清β/α脂蛋白比值较高，其中80人在“盲法”评估中被判定表现出明显的行为模式（A型），以前发现这与中年男性冠心病的发生有关。
This study was designed to (1) compare "predictive" abilities of different parameters and their interrelationships in the future incidence of coronary heart disease (CHD) and (2) define the profile of coronary-prone males through retrospective analysis of prospectively obtained data. Comprehensive studies of overt behavior pattern, blood lipids and coagulation, body measurements, socioeconomic factors, individual habits, and cardiovascular status were obtained annually since 1960 in 3,524 men, aged 39 to 59 years. Manifest CHD was found in 113 of 3,411 "well" men, but this was unknown to the investigators at the time of the study. The men with CHD exhibited higher serum beta/alpha lipoprotein ratios and 80 of them had been adjudged in "blind" assessments to exhibit an overt behavior pattern (type A) previously found associated with occurrence of CHD in middle-aged men.