Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation.
Modulation of GABA and resting state functional connectivity by transcranial direct current stimulation.
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DOI：
10.7554/elife.08789
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发表时间：
2015-09-18
期刊：
影响因子：
7.7
通讯作者：
Stagg CJ
中科院分区：
文献类型：
--
作者：
Bachtiar V;Near J;Johansen-Berg H;Stagg CJ
我们之前证明了人脑中网络水平的功能连通性可能与基线时主要网络节点的抑制水平有关。在这项研究中，我们以这一发现为基础，直接研究了使用经颅直流电刺激(TDC)扰动M1 GABA和静息状态功能连接的影响，这是一种先前已被证明调节这两个指标的神经调制方法。分别在1 mA阳极组和假手术组治疗前和治疗20分钟后，测量脑组织功能磁共振数据和脑内GABA水平。与之前的研究一致，基线GABA水平与静息运动网络内功能连接的强度呈负相关。然而，尽管我们证实了先前报道的结果，即阳极tdcs降低了刺激运动皮质中的GABA浓度并增加了功能连接；但这些变化并不相关，这表明它们可能是由不同的潜在机制驱动的。DOI：http://dx.doi.org/10.7554/eLife.08789.001
We previously demonstrated that network level functional connectivity in the human brain could be related to levels of inhibition in a major network node at baseline. In this study, we build upon this finding to directly investigate the effects of perturbing M1 GABA and resting state functional connectivity using transcranial direct current stimulation (tDCS), a neuromodulatory approach that has previously been demonstrated to modulate both metrics. FMRI data and GABA levels, as assessed by Magnetic Resonance Spectroscopy, were measured before and after 20 min of 1 mA anodal or sham tDCS. In line with previous studies, baseline GABA levels were negatively correlated with the strength of functional connectivity within the resting motor network. However, although we confirm the previously reported findings that anodal tDCS reduces GABA concentration and increases functional connectivity in the stimulated motor cortex; these changes are not correlated, suggesting they may be driven by distinct underlying mechanisms. DOI: http://dx.doi.org/10.7554/eLife.08789.001