Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation.
Plasticity-related microRNA and their potential contribution to the maintenance of long-term potentiation.
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DOI：
10.3389/fnmol.2015.00004
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发表时间：
2015
影响因子：
4.8
通讯作者：
Williams JM
中科院分区：
文献类型：
--
作者：
Ryan B;Joilin G;Williams JM
长期增强（LTP）是突触可塑性的一种形式，是记忆分子机制的一个很好的模型。像记忆一样，LTP是持久的，并且两者都被广泛认为是通过协调的基因组反应来维持的。最近，一类新的非编码RNA microRNA参与了LTP的调控。MicroRNA通过结合特定的信使RNA反应元件负向调节蛋白质合成。本文综述的目的是总结microRNA在LTP调控中起主要作用的实验证据。我们讨论了越来越多的研究表明，特定的microRNA调节与LTP维持相关的突触蛋白，以及研究报道了在LTP诱导下microRNA的差异表达。我们得出结论，microRNA非常适合参与ltp相关基因表达的调控；microRNA是多效性的，位于突触上，受到严格调控，并对突触活动作出反应。作为基因表达的调节因子，microRNA对LTP维持的潜在影响是巨大的。
Long-term potentiation (LTP) is a form of synaptic plasticity that is an excellent model for the molecular mechanisms that underlie memory. LTP, like memory, is persistent, and both are widely believed to be maintained by a coordinated genomic response. Recently, a novel class of non-coding RNA, microRNA, has been implicated in the regulation of LTP. MicroRNA negatively regulate protein synthesis by binding to specific messenger RNA response elements. The aim of this review is to summarize experimental evidence for the proposal that microRNA play a major role in the regulation of LTP. We discuss a growing body of research which indicates that specific microRNA regulate synaptic proteins relevant to LTP maintenance, as well as studies that have reported differential expression of microRNA in response to LTP induction. We conclude that microRNA are ideally suited to contribute to the regulation of LTP-related gene expression; microRNA are pleiotropic, synaptically located, tightly regulated, and function in response to synaptic activity. The potential impact of microRNA on LTP maintenance as regulators of gene expression is enormous.
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影响因子：
16.2
作者：
Edbauer, Dieter;Neilson, Joel R.;Foster, Kelly A.;Wang, Chi-Fong;Seeburg, Daniel P.;Batterton, Matthew N.;Tada, Tomoko;Dolan, Bridget M.;Sharp, Phillip A.;Sheng, Morgan
通讯作者：
Sheng, Morgan
DOI：
10.1523/jneurosci.1312-12.2012
发表时间：
2012-10-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Earls LR;Fricke RG;Yu J;Berry RB;Baldwin LT;Zakharenko SS
通讯作者：
Zakharenko SS
影响因子：
5.3
作者：
Bayazitov, Ildar T.;Richardson, Robert J.;Zakharenko, Stanislav S.
通讯作者：
Zakharenko, Stanislav S.
DOI：
10.1073/pnas.1017576108
发表时间：
2011-07-12
影响因子：
11.1
作者：
Cohen, Jonathan E.;Lee, Philip R.;Fields, R. Douglas
通讯作者：
Fields, R. Douglas
影响因子：
3.5
作者：
Christensen M;Larsen LA;Kauppinen S;Schratt G
通讯作者：
Schratt G