Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.
Prospective multicenter international surveillance of azole resistance in Aspergillus fumigatus.
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DOI：
10.3201/eid2106.140717
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发表时间：
2015-06
影响因子：
11.8
通讯作者：
Verweij PE
中科院分区：
文献类型：
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作者：
van der Linden JW;Arendrup MC;Warris A;Lagrou K;Pelloux H;Hauser PM;Chryssanthou E;Mellado E;Kidd SE;Tortorano AM;Dannaoui E;Gaustad P;Baddley JW;Uekötter A;Lass-Flörl C;Klimko N;Moore CB;Denning DW;Pasqualotto AC;Kibbler C;Arikan-Akdagli S;Andes D;Meletiadis J;Naumiuk L;Nucci M;Melchers WJ;Verweij PE
为了研究临床分离的曲霉菌对唑类药物的耐药性，我们进行了前瞻性多中心国际监测。在来自19个国家的22个中心共筛选了3，788株曲霉菌。抗唑A.烟曲霉菌的发现率（3.2%）比以前承认的要高，它引起耐药的侵袭性和非侵袭性曲霉病，严重影响唑类药物的临床应用。
To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.