High-shear granulation: An investigation into the granule consolidation and layering mechanism
High-shear granulation: An investigation into the granule consolidation and layering mechanism
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DOI：
10.1016/j.powtec.2019.07.076
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发表时间：
2019-10-01
影响因子：
5.2
通讯作者：
Smith, Rachel M.
中科院分区：
文献类型：
--
作者：
de Koster, Stefan A. L.;Pitt, Kate;Smith, Rachel M.
早期颗粒生长的机制很难研究，也知之甚少。整合和分层在增长过程中发挥着关键作用。然而，人们对其动力学知之甚少。在这项工作中，一种新型的纯固结造粒机(COG)被用来只研究动力固结和分层，排除了其他造粒机理。随着时间的推移，研究了有核前颗粒的生长情况。在实验数据和文献模型的基础上，发展了一个用于种群平衡模拟的机械分层核，用已有报道的模型定性地预测了颗粒生长动力学，生长行为与时间的平方根成线性关系，达到一定的临界尺寸后停止生长。X射线计算机断层扫描显示，颗粒的外层主要发生固结。这一结果极大地促进了对固结和层状生长的理解，新模型为改进的预测模型和造粒工艺和产品的设计开辟了道路。皇冠版权(C)2019由爱思唯尔B.V.出版。保留所有权利。
The mechanisms of early granule growth are difficult to study and poorly understood. Consolidation and layering play a critical role in the growth process. However, little is known about the kinetics.In this work, a novel consolidation-only granulator (COG) was used to study dynamic consolidation and layering only, eliminating other granulation mechanisms. Prenucleated granule growth was studied over time. Based on experimental data and literature models, a mechanistic layering kernel for population balance modelling was developed.Granule growth kinetics were qualitatively predicted by a previously reported model; growth behaviour was linear with the square root of time to a certain critical size, after which growth stopped. X-ray computed tomography revealed that consolidation mainly occurred in the outer layers of the granules.The results greatly advance understanding of consolidation and layered growth, and the new model opens the way for improved predictive modelling and design of granulation processes and products. Crown Copyright (C) 2019 Published by Elsevier B.V. All rights reserved.