Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study.
Prevalence and characteristics of transverse myelitis and neuromyelitis optica spectrum disorders in the United Arab Emirates: A multicenter, retrospective study.
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DOI：
10.1111/cen3.12458
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发表时间：
2018-08
影响因子：
--
通讯作者：
Schiess N
中科院分区：
文献类型：
--
作者：
Holroyd KB;Aziz F;Szolics M;Alsaadi T;Levy M;Schiess N
确定阿拉伯联合酋长国阿布扎比横贯性脊髓炎(TM)和视神经脊髓炎谱性疾病(NMOSD)的流行病学和特征。回顾2010至2016年间阿布扎比四家大型公立医院的病历。收集的数据包括发病年份、临床表现、实验室结果(包括水通道蛋白-4免疫球蛋白G(Ig G)/髓鞘少突胶质细胞糖蛋白G抗体)和任何复发的发生。共有46人被确认身份。其中，23人(50%)是阿联酋公民。在包括儿科在内的整个人群中，单相TM的粗略患病率为1.0/10万，NMOSD为0.34/10万。TM和NMOSD在整个人群中的发病率分别为0.18/10万和0.05/10万。20岁的阿联酋人≥的单相TM患病率分别为2.46/10万和1.76/10万，发病率分别为0.57/10万和0.17/10万。在阿联酋儿童人口(19岁≤)中，单相性TM和NMOSD的发病率分别为0.18/10万和0.06/10万。单相性TM的平均发病年龄为36岁，NMOSD的平均发病年龄为43岁。9例水通道蛋白-4或抗髓鞘少突胶质细胞糖蛋白抗体阳性。在有实验室脑脊液分析的30名参与者中，36.6%的人白细胞计数升高(>；5.0×106/L)，43%的人蛋白质水平升高。共有19名参与者有寡克隆条带或免疫球蛋白指数的记录，只有4名(21%)有寡克隆条带或免疫球蛋白指数升高。本研究描述了阿布扎比人群中TM和NMOSD的流行病学和特征。阿联酋公民的成人患病率单相TM为2.46/10万，NMOSD为1.76/10万。总发病率分别为0.18/10万和0.05/10万。
To determine the epidemiology and characteristics of transverse myelitis (TM) and neuromyelitis optica spectrum disorders (NMOSD) in Abu Dhabi, United Arab Emirates. Retrospective chart review at four large government-run hospitals in Abu Dhabi between 2010 and 2016. Data collected included year of onset, presentation, laboratory results including aquaporin-4 immunoglobulin G (IgG)/myelin oligodendrocyte glycoprotein IgG antibodies and the occurrence of any relapses. A total of 46 individuals were identified. Of these, 23 (50%) were Emirati citizens. Within the overall group including pediatrics, the crude prevalence rate for monophasic TM was 1.0 per 100 000, and for NMOSD was 0.34 per 100 000. Incidence rates within the overall group for TM and NMOSD were 0.18 per 100 000 and 0.05 per 100 000, respectively. For Emirati citizens aged ≥20 years, the prevalence rate for monophasic TM was 2.46 per 100 000 and 1.76 per 100 000 for NMOSD, and the incidence was 0.57 per 100 000 and 0.17 per 100 000, respectively. The incidence of monophasic TM and NMOSD within the Emirati pediatric population (aged ≤19 years) was 0.18 per 100 000 and 0.06 per 100 000, respectively. The mean age of onset for monophasic TM was 36 years, and for NMOSD was 43 years. Nine patients had a positive aquaporin-4 IgG or anti-myelin oligodendrocyte glycoprotein IgG antibody result. Of the 30 participants with available laboratory cerebrospinal fluid analysis, 36.6% had elevated white blood counts (>5.0 × 106/L), and 43% had elevated protein levels. A total of 19 participants had documentation of oligoclonal bands or IgG index, and just four (21%) had either oligoclonal bands or elevated IgG index. The present study describes the epidemiology and characteristics of TM and NMOSD among populations in Abu Dhabi. The adult prevalence rate for Emirati citizens was 2.46 per 100 000 for monophasic TM, and 1.76 per 100 000 for NMOSD. The overall incidence was 0.18 per 100 000 and 0.05 per 100 000, respectively.