Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs
Effect of vaccination on serum concentrations of total and antigen-specific immunoglobulin E in dogs
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DOI：
10.2460/ajvr.2002.63.611
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发表时间：
2002-04-01
影响因子：
1
通讯作者：
DeBoer, DJ
中科院分区：
文献类型：
--
作者：
HogenEsch, H;Dunham, AD;DeBoer, DJ
目的研究疫苗接种对犬血清总IgE和抗原特异性IgE浓度的影响。动物：20只雌性比格犬。方法在8周龄至4岁之间，每组5只犬重复接种多价疫苗和狂犬病疫苗、仅多价疫苗或仅狂犬病疫苗。第四组5只犬作为未接种对照。血清中的总免疫球蛋白和抗原特异性IgE浓度测定后vaccination.Results-the多价疫苗血清总IgE浓度的影响不大。在16周龄和1岁时接种狂犬病疫苗后，大多数犬的IgE浓度略有增加，在2岁和3岁时接种疫苗后大幅增加，个体犬之间存在明显差异。接种疫苗对2岁和3岁时测量的伊加、IgG和IgM血清浓度无影响。与多价疫苗相比，狂犬病疫苗含有铝佐剂，在一些接种狂犬病疫苗的犬中检测到与疫苗抗原（包括牛血清白蛋白和牛纤连蛋白）反应的IgE增加。接种后血清总IgE和抗原特异性IgE浓度之间无显著相关性。血清总IgE浓度迅速恢复到pre-immunization浓度在大多数狗，但高浓度的抗原特异性IgE stressed.Conclusions和临床相关性狂犬病疫苗接种的狗增加血清总IgE浓度和诱导特异性IgE疫苗抗原，包括组织培养残留物。在解释血清总IgE浓度时应考虑疫苗接种史。
Objective To determine the effect of vaccination on serum concentrations of total and antigen-specific IgE in dogs.Animals-20 female Beagles.Procedure Groups of 5 dogs each were vaccinated repeatedly between 8 weeks and 4 years of age with a multivalent and rabies vaccine, a multivalent vaccine only, or a rabies vaccine only, A fourth group of 5 dogs served as unvaccinated controls. Serum concentrations of total immunoglobulins and antigen-specific IgE were determined following vaccination.Results-The multivalent vaccine had little effect on serum total IgE concentrations. The concentration of IgE increased slightly following vaccination for rabies at 16 weeks and 1 year of age and increased greatly after vaccination at 2 and 3 years of age in most dogs, with a distinct variation between individual dogs, Vaccination had no effect on serum concentrations of IgA, IgG, and IgM as measured at 2 and 3 years of age. The rabies vaccine contained aluminum adjuvant in contrast to the multivalent vaccine, An increase of IgE that was reactive with vaccine antigens, including bovine serum albumin and bovine fibronectin, was detected in some of the dogs vaccinated for rabies. There was no significant correlation between serum concentrations of total IgE and antigen-specific IgE following vaccination. Serum total IgE concentration rapidly returned to preimmunization concentrations in most dogs, but high concentrations of antigen-specific IgE persisted.Conclusions and Clinical Relevance-Vaccination of dogs for rabies increases serum concentrations of total IgE and induces IgE specific for vaccine antigens, including tissue culture residues. Vaccination history should be considered in the interpretation of serum total IgE concentrations.