In vivo evaluation of porous hydroxyapatite ceramics including bone minerals using pig model
In vivo evaluation of porous hydroxyapatite ceramics including bone minerals using pig model
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DOI：
10.1080/10667857.2018.1495392
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发表时间：
2018-07
影响因子：
3.1
通讯作者：
Tomohiro Yokota;K. Nakano;Masaki Nagaya;M. Honda;H. Nagashima;M. Aizawa
中科院分区：
文献类型：
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作者：
Tomohiro Yokota;K. Nakano;Masaki Nagaya;M. Honda;H. Nagashima;M. Aizawa
摘要我们合成了含有六种离子(Na+、K+、Mg~(2+)、F~(−)、Cl~(−)和CO_(32)−~(2+))的骨矿物(骨羟基磷灰石)。在本研究中，我们通过将骨羟基磷灰石粉末植入猪的软组织和硬组织中，对多孔陶瓷进行了体内评价。添加碳珠作为致孔剂对骨-羟基磷灰石陶瓷的晶相影响不大，但在二氧化碳气氛中烧成会降低其机械强度。植入软组织的骨羟基磷灰石多孔陶瓷不具有骨诱导活性，但与单纯的羟基磷灰石植入骨组织相比，具有更好的生物吸收能力和骨传导性。这些结果表明，多离子替代的协同效应可能提高骨HAP陶瓷的生物吸收率和骨传导性。
ABSTRACT We synthesized HAp including bone minerals (bone HAp) comprising six ions present in living bone (Na+, K+, Mg2+, F−, Cl− and CO32− ions). In this study, we performed in vivo evaluation of porous ceramics fabricated from bone HAp powders by implantation into porcine soft and hard tissues. Addition of carbon beads as porogens had little effect on the crystalline phase of bone HAp ceramics, but firing in a CO2 gas atmosphere resulted in reduced mechanical strength. Bone HAp porous ceramics implanted in soft tissues did not exhibit osteoinductivity, but showed superior bioresorbability and osteoconductivity when compared with pure HAp in the case of implantation into bone tissue. These results suggested that synergistic effects due to the substitution of multiple ions may enhance bioresorbability and osteoconductivity of bone HAp ceramics.