Anti-allergic agents from natural sources (4):: Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)
Anti-allergic agents from natural sources (4):: Anti-allergic activity of new phloroglucinol derivatives from Mallotus philippensis (Euphorbiaceae)
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DOI：
10.1248/cpb.50.1566
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发表时间：
2002-12-01
影响因子：
1.7
通讯作者：
Kitanaka, S
中科院分区：
文献类型：
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作者：
Daikonya, A;Katsuki, S;Kitanaka, S
从菲律宾马丽莲果实中分离到两个新的间苯三酚衍生物mallotopphilipen A(1)和B(2)。通过化学和光谱数据鉴定，这些化合物分别为1-[5,7-二羟基-2,2-二甲基-6-（2,4,6-三羟基-3-异丁基-5-甲基苄基）-2 -甲基丁烷-1- 1和1-[6-（3-乙酰基-2,4,6-三羟基-5-甲基苄基）-5,7-二羟基-2,2-二甲基-2-甲基丁烷-8- 1]-2-甲基丁烷-1- 1。通过脂多糖（LPS）和重组小鼠干扰素γ (ifn - γ)激活小鼠巨噬细胞样细胞株（RAW 264.7），抑制一氧化氮（NO）的产生并诱导NO合成酶（iNOS）基因的表达。此外，它们还能抑制化合物48/80诱导的大鼠腹膜肥大细胞释放组胺。这些结果表明，新型间苯三酚衍生物具有抗炎作用。
Two new phloroglucinol derivatives, mallotophilippen A (1) and B (2) were isolated from the fruits of Mallotus philippensis. These compounds were identified, using chemical and spectral data, as 1-[5,7-dihydroxy-2,2-dimethyl-6-(2,4,6-trihydroxy-3-isobutyryl-5-methyl-benzyl)-2H-chromen-8-yl] -2-methyl-butan-1-one and 1-[6-(3-Acetyl-2,4,6-trihydroxy-5-methyl-benzyl)-5,7-dihydroxy-2,2-dimethyl-2H-chromen-8-yl] -2-methyl-butan-1-one, respectively. They inhibited nitric oxide (NO) production and inducible NO synthase (iNOS) gene expression by a murine macrophage-like cell line (RAW 264.7), which was activated by lipopolysaccharide (LPS) and recombinant mouse interferon-gamma (IFN-gamma). Furthermore, they inhibited histamine release from rat peritoneal mast cells induced by Compound 48/80. These results suggest that the novel phloroglucinol derivatives have anti-inflammatory effects.