Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
Dietary choline and betaine assessed by food-frequency questionnaire in relation to plasma total homocysteine concentration in the Framingham Offspring Study
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DOI：
10.1093/ajcn/83.4.905
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发表时间：
2006-04-01
影响因子：
7.1
通讯作者：
Willett, WC
中科院分区：
文献类型：
--
作者：
Cho, E;Zeisel, SH;Willett, WC
背景资料：胆碱和甜菜碱摄入量的流行病学研究很少，因为直到最近才有食物成分数据库。一般人群中饮食胆碱和甜菜碱变化的生理相关性和食物频率问卷（FFQ）评估的摄入有效性尚未评估。目的：本研究旨在检查所有FFQ测量的胆碱和甜菜碱摄入的生理相关性和有效性。设计：我们研究了1960名来自Frachial Offspring Study的参与者中通过FFQ测量的胆碱和甜菜碱摄入量与血浆总同型半胱氨酸（tHcy）浓度之间的关系。较高的膳食胆碱和甜菜碱摄入量与较低的tHcy浓度相关，而不依赖于其他决定因素，包括叶酸和其他B族维生素。对于最低和最高五分之一的饮食胆碱加甜菜碱，tHcy的多变量几何平均值分别为10.9和9.9 μ mol/L（趋势P < 0.0001）。这种负相关主要表现在叶酸摄入量低的参与者中（交互作用P < 0.0001）。在叶酸摄入量
Background: Epidemiologic studies of choline and betaine intakes have been sparse because a food-composition database was not available until recently. The physiologic relevance of a variation in dietary choline and betaine in the general population and the validity of intake assessed by food-frequency questionnaire (FFQ) have not been evaluated.Objective: This study was conducted to examine the physiologic relevance and validity of choline and betaine intakes measured by all FFQ.Design: We examined the relations between choline and betaine intakes measured by FFQ and plasma total homocysteine (tHcy) concentrations in 1960 participants from the Framingham Offspring Study.Results: Higher intakes of dietary choline and betaine were related to lower tHcy concentrations independent of other determinants, including folate and other B vitamins. For the lowest and highest quintiles of dietary choline plus betaine, the multivariate geometric means for tHcy were 10.9 and 9.9 mu mol/L (P for trend < 0.0001). The inverse association was manifested primarily in participants with low folate intakes (P for interaction < 0.0001). Among participants with folate intakes