Functional changes in deep dorsal horn interneurons following spinal cord injury are enhanced with different durations of exercise training
Functional changes in deep dorsal horn interneurons following spinal cord injury are enhanced with different durations of exercise training
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脊髓损伤后深部背角中间神经元的功能变化随着不同持续时间的运动训练而增强
DOI：
10.1113/jphysiol.2014.282640
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Robert J. Callister
中科院分区：
文献类型：
--
作者：
M. Rank;J. R. Flynn;Camila R. Battistuzzo;Mary P. Galea;Robert J. Callister;Robert J. Callister
脊髓损伤（SCI）后的运动训练增强了损伤附近轴突的侧支发芽，并被认为促进了有效桥接SCI的脊髓内回路重组。运动训练及其持续时间对这些从头脊髓内回路中的中间神经元的影响知之甚少。在成年小鼠SCI半切模型中，我们使用全细胞膜片钳电生理学检查了SCI附近深背角中间神经元对损伤的反应以及3周和6周跑步机运动训练后的内在和突触特性的变化。SCI单独产生强大的影响，内在的和突触性质的中间神经元附近的病变。重要的是，运动训练优先增强了局部和下行的突触活动，这表明运动促进了脊髓中间神经元的突触可塑性，这些中间神经元在SCI后形成新的脊髓内回路。
Exercise training after spinal cord injury (SCI) enhances collateral sprouting from axons near the injury and is thought to promote intraspinal circuit reorganisation that effectively bridges the SCI. The effects of exercise training, and its duration, on interneurons in these de novo intraspinal circuits are poorly understood. In an adult mouse hemisection model of SCI, we used whole‐cell patch‐clamp electrophysiology to examine changes in the intrinsic and synaptic properties of deep dorsal horn interneurons in the vicinity of a SCI in response to the injury, and after 3 and 6 weeks of treadmill exercise training. SCI alone exerted powerful effects on the intrinsic and synaptic properties of interneurons near the lesion. Importantly, synaptic activity, both local and descending, was preferentially enhanced by exercise training, suggesting that exercise promotes synaptic plasticity in spinal cord interneurons that are ideally placed to form new intraspinal circuits after SCI.
影响因子：
2.5
作者：
de Leon, RD;Hodgson, JA;Edgerton, VR
通讯作者：
Edgerton, VR
影响因子：
2.5
作者：
YOSHIMURA, M;JESSELL, TM
通讯作者：
JESSELL, TM