The Advantages of Indocyanine Green Fluorescence Imaging in Detecting and Treating Pediatric Hepatoblastoma: A Preliminary Experience.
The Advantages of Indocyanine Green Fluorescence Imaging in Detecting and Treating Pediatric Hepatoblastoma: A Preliminary Experience.
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吲哚菁绿色荧光显像在儿童肝母细胞瘤诊断和治疗中的优势：初步经验。
DOI：
10.3389/fped.2021.635394
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发表时间：
2021
影响因子：
2.6
通讯作者：
Kim SC
中科院分区：
文献类型：
--
作者：
Cho YJ;Namgoong JM;Kwon HH;Kwon YJ;Kim DY;Kim SC
背景资料：目前，吲哚菁绿色（ICG）荧光成像能够在肝母细胞瘤（HB）中进行根治性手术切除，并具有有益的用途;然而，其在儿科患者中的使用仍然有限。方法：2015年至2019年，17例肝母细胞瘤患者接受了22例使用ICG的荧光引导手术。术前24-48 h静脉注射ICG（0.3mg/kg）。利用ICG/NIR摄像机，进行术中生物结构识别和肿块划界。结果如下：在22例肝母细胞瘤患者中进行了ICG荧光引导手术：16例接受解剖切除术，1例接受部分肝切除术，2例接受肝移植术。6例患者在手术时伴有肺转移，2例患者接受了使用ICG的肺手术。从ICG注射到手术的中位间隔为38.3小时（范围，20.5-50.3小时）。中位肿瘤大小为36.5 mm（范围，2-132 mm）。根据病理结果，安全边界中位数为6 mm（范围：0-11 mm），随访计算机断层扫描（CT）时肝脏无残留结果。结论：ICG荧光显像在儿童HB中用于肿瘤分界和提高肿瘤根治性切除的准确性是可行和安全的。
Background: Currently, indocyanine green (ICG) fluorescence imaging enables radical surgical resection in hepatoblastoma (HB) and has beneficial uses; however, its usage in pediatric patients is still limited. Methods: From 2015 to 2019, 17 hepatoblastoma patients underwent 22 fluorescence-guided surgery using ICG. ICG (0.3 mg/kg) was intravenously injected 24–48 h before the operation. With ICG/NIR camera, intraoperative identification of biological structures and demarcation of mass were conducted. Results: ICG fluorescence-guided surgery was performed for hepatoblastoma in 22 cases: 16, 1, and 2 cases underwent anatomic resection, partial hepatectomy, and liver transplantation, respectively. Six patients accompanied lung metastasis at the time of surgery, and two patients underwent lung surgery using ICG. The median interval from ICG injection to surgery was 38.3 h (range, 20.5–50.3 h). The median tumor size was 36.5 mm (range, 2–132 mm). According to the pathologic finding, the median safety margin was secured for 6 mm (range, 0–11 mm) and there was no residual finding at the liver at the follow-up computed tomography (CT). Conclusions: ICG fluorescence imaging in children with HB was feasible and safe for tumor demarcation and enhancing the accuracy of radical tumor resection.
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影响因子：
6.2
作者：
Ishizawa, Takeaki;Fukushima, Noriyoshi;Kokudo, Norihiro
通讯作者：
Kokudo, Norihiro
DOI：
10.1089/lap.2017.0735
发表时间：
2018-09-01
影响因子：
1.3
作者：
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6.2
作者：
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通讯作者：
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影响因子：
2.4
作者：
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通讯作者：
Usui, Noriaki
影响因子：
0.4
作者：
Mitani, Yasuyuki;Kubota, Akio;Yamaue, Hiroki
通讯作者：
Yamaue, Hiroki