Focal thinning of the posterior corpus callosum: Normal variant or post-traumatic?
Focal thinning of the posterior corpus callosum: Normal variant or post-traumatic?
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DOI：
10.3109/02699052.2011.589791
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发表时间：
2011-09-01
期刊：
影响因子：
1.9
通讯作者：
Anderson, Vicki
中科院分区：
文献类型：
--
作者：
Beauchamp, Miriam H.;Ditchfield, Michael;Anderson, Vicki
目的：胼胝体（CC）可受儿童创伤性脑损伤（TBI）的影响，通过局灶性病变，大小减少和发育受阻。然而，关于早期脑外伤后正常CC形状和外观的构成以及它如何长期受到影响，我们所知甚少。方法：在本研究中，对损伤后10年评估的TBI患者（n = 52，平均年龄= 16.82岁，SD = 3.55岁，男性24人）的CC外观进行了调查，并与年龄匹配的健康对照（n = 44，平均年龄= 15.77岁，SD = 1.21岁，男性18人）进行了比较。根据病灶变薄的位置和变薄的严重程度，采用简单的视觉分析技术对CC的外观进行编码，并使用卡方分析比较组间结果。结果：儿童TBI患者的CC后部局灶性变薄的比例明显高于年龄匹配的对照组（p = 0.001）。结论：研究结果对先前的结论提出了质疑，即局灶性后部变薄是一种正常的发育变体。相反，长期来看，CC后部的减弱可能反映了早期脑损伤导致的皮质和胼胝体发育的改变，尽管其功能意义仍有待确定。
Aim: The corpus callosum (CC) can be affected by childhood traumatic brain injury (TBI), through focal lesions, reductions in size and arrested development. Little is known, however, about what constitutes normal CC shape and appearance and how it may be affected in the long-term after early TBI.Methods: In this study, the appearance of the CC was investigated in individuals with TBI assessed 10 years post-injury (n = 52, mean age = 16.82 years, SD = 3.55 years, 24 male) and compared to age-matched healthy controls (n = 44, mean age = 15.77 years, SD = 1.21 years, 18 male). A simple visual analysis technique was used to code the appearance of the CC according to location of focal thinning and severity of thinning and results between groups were compared using Chi-square analysis.Results: A significantly higher proportion of patients with childhood TBI had focal posterior thinning of the CC than age-matched controls (p = 0.001).Conclusions: The findings call into question previous conclusions that focal posterior thinning is a normal variant of development. Instead, attenuations of the posterior portion of the CC in the long-term may reflect altered cortical and callosal development as a result of early brain injury, although the functional significance of this remains to be determined.