Prevalence and Characteristics of Primary Angle-Closure Diseases in a Rural Adult Chinese Population: The Handan Eye Study
Prevalence and Characteristics of Primary Angle-Closure Diseases in a Rural Adult Chinese Population: The Handan Eye Study
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DOI：
10.1167/iovs.11-7480
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发表时间：
2011-11-01
影响因子：
4.4
通讯作者：
Wang, Ning Li
中科院分区：
文献类型：
--
作者：
Liang, Yuanbo;Friedman, David S.;Wang, Ning Li
目的。调查中国农村人群原发性闭角疑似病(PACS)、原发性闭角型青光眼(PACG)和原发性闭角型青光眼(PACG)的患病率和特点。随机抽取邯郸市13个村庄的6716名30岁及以上汉族人（5480名40岁及以上受试者）完成眼科检查，包括视力、眼压（IOP）、裂隙灯检查、房角镜检查和立体摄影以及视野。如果任一只眼在房角镜检查中 180 度或以上不可见后小梁网，则定义为存在 PACS。患有 PACS 和周围性前粘连 (PAS) 和/或 IOP >= 21 mm Hg，但没有青光眼神经病 (GON) 的眼睛中存在 PAC。 PACG 被定义为具有 GON.RESULTS 证据的 PAC。 40 岁及以上人群中 PACG、PAC 和 PACS 的标准化患病率分别为 0.5%（95% 置信区间 [CI]：0.3-0.7%）、1.5%（95% CI：1.2-1.8%）和 10.4%（95% CI：9.6-11.2%）。所有三种疾病的患病率均随着年龄的增长而增加（P < 0.001）。女性的PACS、PAC和PACG发生率明显更高（P < 0.05）； 21 名 PACG 患者 (65%) 至少一只眼睛失明：13 名因青光眼而失明，另外 8 名可能有其他原因。结论。该农村人口中 PACS、PAC 和 PACG 的患病率与之前报道的中国城市居民相似。三分之二的 PACG 患者至少一只眼睛失明。中国农村地区需要制定检测和治疗这种可预防疾病的策略。 （投资眼科可见科学。2011；52：8672-8679）DOI：10.1167/iovs.11-7480
PURPOSE. To investigate the prevalence and characteristics of primary angle-closure suspect (PACS), primary angle closure (PAC), and primary angle-closure glaucoma (PACG) in a rural population in China.METHODS. In all, 6716 Han Chinese 30 years of age and older (5480 subjects 40 years of age and older) from 13 villages in Handan were randomly selected and completed an ophthalmologic examination, including visual acuity, intraocular pressure (IOP), slit-lamp examination, gonioscopy and stereoscopic photography, and visual field. PACS was defined as present if either eye had the posterior trabecular meshwork not visible for 180 degrees or more on gonioscopy. PAC was present in an eye with PACS and peripheral anterior synechiae (PAS) and/or IOP >= 21 mm Hg, but without glaucomatous neuropathy (GON). PACG was defined as PAC with evidence of GON.RESULTS. The standardized prevalences of PACG, PAC, and PACS were 0.5% (95% confidence interval [CI]: 0.3-0.7%), 1.5% (95% CI: 1.2-1.8%), and 10.4% (95% CI: 9.6-11.2%) in those 40 years of age and older. The prevalence of all three conditions increased with age (P < 0.001). Females had much higher rates of PACS, PAC, and PACG (P < 0.05); 21 persons with PACG (65%) were blind in at least one eye: 13 were due to glaucoma and the other 8 likely had other causes.CONCLUSIONS. The prevalence of PACS, PAC, and PACG in this rural population is similar to what was previously reported in urban Chinese residents. Two thirds of those with PACG were blind in at least one eye. Strategies to detect and treat this preventable disease in rural China are needed. (Invest Ophthalmol Vis Sci. 2011;52:8672-8679) DOI: 10.1167/iovs.11-7480