Polydrug- and methadone-addicted newborns: a continuum of impairment?
Polydrug- and methadone-addicted newborns: a continuum of impairment?
复制标题
对多种药物和美沙酮成瘾的新生儿：连续的损害？
作者：
I. Chasnoff;R. Hatcher;William J. Burns
在一项前瞻性对照研究中，对吸毒母亲所生的两组婴儿进行了评估，并与第三个对照组进行了比较。第一组婴儿（N = 39）出生的母亲控制良好的低剂量美沙酮维持。第二组婴儿（N = 19）是由滥用多种药物的母亲所生，第三组婴儿（N = 27）是由没有药物滥用史或证据的对照母亲所生。所有三组都匹配了可能影响新生儿结局的母体因素。I组婴儿的所有生长测量值均显著小于对照组婴儿，头围显著小于II组婴儿。利用Brazelton新生儿行为评估量表，I组婴儿表现出更多的抑郁症的互动行为和状态控制比II组婴儿，谁又比III组婴儿更抑郁。非麻醉性药物对宫内生长和新生儿行为的影响似乎将多药成瘾新生儿置于正常和阿片类成瘾新生儿之间的中间区域。
Two groups of infants born to drug-addicted mothers were evaluated in a prospective controlled study and compared with a third control group. Group I infants (N = 39) were born to mothers on well-controlled low-dose methadone maintenance. Group II infants (N = 19) were born to polydrug-abusing mothers, and group III infants (N = 27) were born to control mothers who had no history or evidence of drug abuse. All three groups were matched for maternal factors that might affect neonatal outcome. Group I infants were significantly smaller than control infants for all growth measurements and had a significantly smaller head circumference than group II infants. Utilizing the Brazelton Neonatal Behavioral Assessment Scale, group I infants showed more depression of interactive behaviors and state controls than group II infants, who in turn were more depressed than group III infants. The effects of nonnarcotic drugs on intrauterine growth and neonatal behavior appear to place the polydrug-addicted newborn in an intermediate zone of deficit between normal and opiate-addicted newborns.