Sirtuins: a conserved key unlocking AceCS activity
Sirtuins: a conserved key unlocking AceCS activity
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DOI：
10.1016/j.tibs.2006.11.002
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发表时间：
2007-01-01
影响因子：
13.8
通讯作者：
Sinclair, David A.
中科院分区：
文献类型：
--
作者：
North, Brian J.;Sinclair, David A.
细菌乙酰辅酶A合成酶（AceCS）是一种进化上保守的将乙酸盐转化为乙酰辅酶A的酶，通过沉默调节蛋白介导的去乙酰化作用而被激活。最近的两项研究表明，这种调节机制对哺乳动物AceCS活性也是至关重要的，表明在将乙酸转化为乙酰辅酶A的步骤中对代谢的控制是保守的。这些发现突出了由sirtuins控制的代谢调节网络，其对卡路里限制和哺乳动物寿命调节的机制具有影响。
Bacterial acetyl-coenzyme A (acetyl-CoA) synthetase (AceCS), an evolutionarily conserved enzyme that converts acetate to acetyl-CoA, is activated by sirtuin-mediated deacetylation. Two recent studies show that this mechanism of regulation is also crucial for mammalian AceCS activity, indicating that control of metabolism at the step of converting acetate to acetyl-CoA is conserved. These findings highlight a metabolic regulatory network controlled by sirtuins that has implications for the mechanisms of calorie restriction and modulation of mammalian lifespan.