Fibrinogen-fibrin interactions with fibroblasts and macrophages.
Fibrinogen-fibrin interactions with fibroblasts and macrophages.
复制标题
纤维蛋白原-纤维蛋白与成纤维细胞和巨噬细胞的相互作用。
DOI：
10.1111/j.1749-6632.1983.tb23279.x
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发表时间：
1983
影响因子：
5.2
通讯作者：
Colvin,RB
中科院分区：
文献类型：
--
作者：
Colvin,RB
其他人已经表明，成纤维细胞与纤维蛋白积极相互作用，这是通过它们介导凝块收缩的能力来判断的，14并且这种特性在病毒转化时丢失。成纤维细胞与交联纤维蛋白和纤连蛋白的粘附也已得到充分证明。 16 最后，可溶性纤连蛋白（或片段）可以作为成纤维细胞的趋化剂。因此，纤维蛋白-纤连蛋白临时基质可能是影响炎症反应中成纤维细胞迁移和定位的候选基质。肿瘤细胞（包括恶性成纤维细胞）结合纤维蛋白原和介导凝块收缩的能力减弱的观察结果具有一定的意义。这是否会影响它们在组织中的锚定或恶性行为仍然是推测。
Others have shown that fibroblasts actively interact with fibrin, as judged by their ability to mediate clot retraction, 14 and that this property is lost on viral tran~ formation.'~ The adherence of fibroblasts to cross-linked fibrin and fibronectin also has been well documented. 16 Finally, soluble fibronectin (or fragments) can serve as a chemotactic agent for fibroblasts. lT, Thus the fibrin-fibronectin provisional matrix is a likely candidate for influencing fibroblast migration and localization in inflammatory reactions. The observations that tumor cells (including malignant fibroblasts) have diminished capacity to bind fibrinogen and mediate clot retraction is of some intere~ t.'~ Whether this affects their anchorage in tissue or malignant behavior remains speculative.