CaT1 expression correlates with tumor grade in prostate cancer
CaT1 expression correlates with tumor grade in prostate cancer
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DOI：
10.1006/bbrc.2001.4638
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发表时间：
2001-04-06
影响因子：
3.1
通讯作者：
Freeman, MR
中科院分区：
文献类型：
--
作者：
Peng, JB;Zhuang, LY;Freeman, MR
钙信号对前列腺癌(Pca)细胞的生长和存活具有重要作用。在此，我们报道了一种对钙离子高度选择性的通道蛋白CaT1基因在人前列腺癌和LNCaP前列腺癌细胞系中的高水平表达。与良性前列腺增生症(BPH)相比，前列腺癌组织中CaT1基因的表达水平升高，并与PCa的Gleason分级呈正相关。在LNCaP鳗鱼中，CaT1基因被雄激素抑制，并被一种特异的雄激素受体拮抗剂诱导，表明该基因受雄激素负调控。这些发现首次表明钙通道参与了前列腺癌的进展，并提示CaT1可能是一个新的治疗靶点。(C)2001年学术出版社。
Ca2+ signaling is important for growth and survival of prostatic carcinoma (PCa) cells. Here we report that the gene for CaT1, a channel protein highly selective for Ca2+, is expressed at high levels in human PCa and in the LNCaP PCa cell line, CaT1 mRNA levels were elevated in PCa specimens in comparison to benign prostatic hyperplasia (BPH) specimens and positively correlated with Gleason grade in a PCa series. CaT1 mRNA was suppressed by androgen and was induced by a specific androgen receptor antagonist in LNCaP eels, suggesting that the gene is negatively regulated by androgen. These findings are the first to implicate a Ca2+ channel in PCa progression and suggest that CaT1 may be a novel target for therapy. (C) 2001 Academic Press.