Basal ganglia-thalamocortical circuitry disruptions in schizophrenia during delayed response tasks
Basal ganglia-thalamocortical circuitry disruptions in schizophrenia during delayed response tasks
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DOI：
10.1016/j.biopsych.2005.11.014
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发表时间：
2006-08-01
影响因子：
10.6
通讯作者：
McDowell, Jennifer E.
中科院分区：
文献类型：
--
作者：
Camchong, Jazmin;Dyckman, Kara A.;McDowell, Jennifer E.
背景：精神分裂症的特征是执行功能缺陷，可能是由前额叶皮质功能障碍介导的。例如，精神分裂症患者在眼动延迟反应（ODR）任务中表现出绩效缺陷，该任务需要抑制能力和空间工作记忆才能正确完成。
方法：本项功能性磁共振成像（fMRI）研究比较了14名精神分裂症患者和14名正常参与者在执行ODR任务时的神经活动。
结果：精神分裂症患者出现：1）更多预期性扫视（在延迟期间进行的扫视）的试验，2）潜伏期更长的记忆性扫视，以及3）准确性降低的记忆性扫视。在两组中，眼动回路（例如，辅助眼区[SEF]、外侧额叶眼区[FEF]、顶下小叶[IPL]、楔叶和楔前叶）都观察到血氧水平依赖（BOLD）信号变化增加。正常组，但不是精神分裂症组，在背外侧前额叶区域（右侧布罗德曼区[BA]9和双侧BA 10）、内侧FEF、岛叶、丘脑和基底神经节显示出BOLD信号变化。预期性扫视试验百分比与BOLD信号变化之间的相关性在两组间对于皮质下区域更为相似，而对于皮质区域则不太相似。
结论：这些结果表明，精神分裂症的执行功能缺陷可能与基底神经节 - 丘脑 - 皮质回路功能障碍有关，这在ODR任务执行过程中表现为精神分裂症组前额叶皮质、基底神经节和丘脑活动降低。
Background: Schizophrenia is characterized by executive functioning dqficits, presumably mediated by prefrontal cortex dysfunction. For example, schizopbrenia participants show performance deficits on ocular motor delayed response (ODR) tasks, which require both inhibition and spatial working memory for correct performance.Methods: The present functional magnetic resonance imaging (fMRI) study compared neural activity of 14 schizophrenia and 14 normal participants while they performed ODR tasks.Results. Schizopbrenia participants generated: 1) more trials with anticipatory saccades (saccades made during the delay period), 2) memory saccades with longer latencies, and 3) memory saccades of decreased accuracy. Increased blood oxygenation level-dependent (BOLD) signal changes were observed in both groups in ocular motor circuitry (e.g., supplementary eye fields [SEF], lateral frontal eye fields [FEF], inferior parietal lobule [IPL], cuneus, and precuneus). The normal, but not the schizophrenia, group demonstrated BOLD signal changes in dorsolateral profrontal regions (right Brodmann area [BA] 9 and bilateral BA 10), medial FEF, insula, thalamus, and basal ganglia. Correlations between percentage of anticipatory saccade trials and BOLD signal changes were more similar between groups for subcortical regions and less similar for cortical regions.Conclusions: These results suggest that executive functioning deficits in schizophrenia may be associated with dysfunction of the basal ganglia-thalamocortical circuitry, evidenced by decreased prefrontal cortex, basal ganglia, and thalamus activity in the schizophrenia group during ODR task performance.