Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men
Effects of green tea extracts on non-shivering thermogenesis during mild cold exposure in young men
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DOI：
10.1017/s0007114512005089
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发表时间：
2013-07-28
影响因子：
3.6
通讯作者：
Haman, Francois
中科院分区：
文献类型：
--
作者：
Gosselin, Chantal;Haman, Francois
表没食子儿茶素没食子酸酯（EGCG）和咖啡因对冷暴露期间非颤抖性产热（NST）的影响尚不清楚。本研究的目的是量化的影响，共同ingcubic EGCG和咖啡因的产热反应的3小时冷暴露。共有8名健康男性暴露于轻度寒冷，使用灌注有15摄氏度水的液体调节服，两次并食用安慰剂或1600 mg EGCG和600 mg咖啡因的提取物（绿色茶）。在基线和冷暴露期间监测热，代谢和肌电图测量。结果显示，与安慰剂（332（SEM 69）% MVC x min）相比，绿色茶（266（SEM 6）%最大自主收缩（MVC）x min）治疗中冷暴露期间寒战强度的AUC降低约20%（P=0.01）。相比之下，与安慰剂（327（SEM 74）kJ/kg 180 min）相比，绿色茶（23.5（SEM 1.4）kJ/kg x 180 min）中能量消耗（EE）的总AUC高约10%（P=0.007）。在寒冷暴露期间摄入EGCG和咖啡因后，颤抖活动的减少与EE的增加相结合，表明NST途径可以在成年人受试者中被显著刺激。本研究提供了一个实验方法，人类调查的潜在作用，饮食和生物活性食品成分在调节NST在寒冷暴露。以这种方式刺激NST通路也可以在寻找用于管理肥胖和糖尿病的靶标中提供重要靶标。
The effects of epigallocatechin-3-gallate (EGCG) and caffeine on non-shivering thermogenesis (NST) during cold exposure is unknown. The purpose of the present study was to quantify the effects of co-ingesting EGCG and caffeine on the thermogenic responses of a 3 h cold exposure. A total of eight healthy males were exposed to mild cold, using a liquid-conditioned suit perfused with 15 degrees C water, on two occasions and consumed a placebo or an extract of 1600 mg of EGCG and 600 mg of caffeine (Green tea). Thermic, metabolic and electromyographic measurements were monitored at baseline and during the cold exposure. Results showed that the AUC of shivering intensity over the cold exposure period was reduced by approximately 20% in the Green tea (266 (SEM 6)% maximal voluntary contraction (MVC) x min) compared with the Placebo (332 (SEM 69)% MVC x min) (P=0.01) treatments. In contrast, the total AUC for energy expenditure (EE) was approximately 10% higher in the Green tea (23.5 (SEM 1.4) kJ/kg x 180 min) compared with the Placebo (327 (SEM 74) kJ/kg 180 min) (P=0.007) treatments. The decrease in shivering activity combined with an increase in EE, following the ingestion of EGCG and caffeine during the cold exposure, indicates that NST pathways can be significantly stimulated in adult human subjects. The present study provides an experimental approach for human investigations into the potential role of diet and bioactive food ingredients in modulating NST during cold exposure. Stimulating NST pathways in such a manner may also provide important targets in the search of targets for the management of obesity and diabetes.