Large-Scale Microelectrode Recordings of High-Frequency Gamma Oscillations in Human Cortex during Sleep
Large-Scale Microelectrode Recordings of High-Frequency Gamma Oscillations in Human Cortex during Sleep
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DOI：
10.1523/jneurosci.5049-09.2010
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发表时间：
2010-06-09
影响因子：
5.3
通讯作者：
Engel, Jerome
中科院分区：
文献类型：
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作者：
Le Van Quyen, Michel;Staba, Richard;Engel, Jerome
伽马振荡（40-120 Hz）通常与清醒功能相关，可以在动物睡眠的最深阶段被记录下来。它们跨多个皮质网络的大规模协调的全部细节仍然未知。此外，尚不清楚人脑中是否也存在具有类似特征的振荡。在这项研究中，我们使用大规模微电极记录（多达 56 个通道），以单细胞和尖峰时间精度，检查了癫痫患者在多导睡眠图定义的睡眠-觉醒状态下是否存在伽马振荡。我们报告说，在慢波睡眠期间，在所有研究的皮层区域中，低（40-80 Hz）和高（80-120 Hz）伽马振荡反复出现数百毫秒的加班窗口。这些模式与脑电图慢振荡的正峰值和局部细胞放电的显着增加相关，表明它们与皮质向上状态有关。这些伽马振荡经常几乎同时出现在许多不同的皮质区域，包括同伦区域，形成大的空间模式。在伽玛振荡期间，毫秒精度的同时放电得到了强烈增强，但仅限于同一皮质区域内的细胞之间。此外，在很多情况下，皮质伽马振荡往往发生在海马波纹/尖波复合体之后 100 毫秒内。这些数据证实并扩展了早期的动物研究报告，伽马振荡在睡眠期间的 UP 状态下短暂表达。我们推测这些高频模式会短暂恢复“微唤醒”活动，对于巩固之前清醒时期获得的记忆痕迹非常重要。
Gamma oscillations (40-120 Hz), usually associated with waking functions, can be recorded in the deepest stages of sleep in animals. The full details of their large-scale coordination across multiple cortical networks are still unknown. Furthermore, it is not known whether oscillations with similar characteristics are also present in the human brain. In this study, we examined the existence of gamma oscillations during poly-somnographically defined sleep-wake states using large-scale microelectrode recordings (up to 56 channels), with single-cell and spike-time precision, in epilepsy patients. We report that low (40-80 Hz) and high(80-120 Hz) gamma oscillations recurrently emerged overtime windows of several hundreds of milliseconds in all investigated cortical areas during slow-wave sleep. These patterns were correlated with positive peaks of EEG slow oscillations and marked increases in local cellular discharges, suggesting that they were associated with cortical UP states. These gamma oscillations frequently appeared at approximately the same time in many different cortical areas, including homotopic regions, forming large spatial patterns. Coincident firings with millisecond precision were strongly enhanced during gamma oscillations but only between cells within the same cortical area. Furthermore, in a significant number of cases, cortical gamma oscillations tended to occur within 100 ms after hippocampal ripple/sharp wave complexes. These data confirm and extend earlier animal studies reporting that gamma oscillations are transiently expressed during UP states during sleep. We speculate that these high-frequency patterns briefly restore "microwake" activity and are important for consolidation of memory traces acquired during previous awake periods.