Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner
Gamma tACS over M1 and cerebellar hemisphere improves motor performance in a phase-specific manner
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DOI：
10.1016/j.neulet.2018.11.015
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发表时间：
2019-02-16
影响因子：
2.5
通讯作者：
Onishi, Hideaki
中科院分区：
文献类型：
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作者：
Miyaguchi, Shota;Otsuru, Naofumi;Onishi, Hideaki
经颅交流电刺激(TACS)调节电极下方皮质区域的神经连接。虽然已经证明，在M1和小脑半球上使用伽玛TAC可以改善运动能力，但这种影响的细节仍不清楚。本研究旨在阐明伽玛Tacs对M1和小脑半球的影响是否具有时相特异性。对20名健康成人用右手食指进行视觉运动控制时，对20名健康成人进行左侧M1和右侧小脑半球70赫兹的TACS，刺激条件有三种：(1)假刺激(假刺激)，(2)两皮质靶区180度位相差(反相条件)，(3)0度位相差(同相条件)。反相条件下的作业错误比假条件下的少(P=0.021)，但与同相条件下的差异不显著。我们的研究表明，伽玛Tacs对M1和小脑半球的影响具有相特异性。这一结果表明，皮质间功能同步参与了在M1和小脑半球进行伽玛TAC时运动能力的改善。
Transcranial alternating current stimulation (tACS) modulates neural connectivity in the cortical area under the electrodes. Although gamma tACS over the M1 and the cerebellar hemisphere has been shown to improve motor performance, the details of this effect remain unclear. This study aimed to clarify whether the effect of gamma tACS over the M1 and the cerebellar hemisphere is a phase-specific. We applied tACS at 70 Hz over the left M1 and the right cerebellar hemisphere to 20 healthy adults while they performed a visuomotor control task using their right index finger for 30 s. Three stimulation conditions were applied: (1) pseudo-stimulation (sham condition), (2) 180 degrees phase difference in the two cortical target areas (anti-phase condition) and (3) 0 degrees phase difference (in-phase condition). The anti-phase condition decreased task error compared to the sham condition (P = 0.021), but did not differ from the in-phase condition. Our study demonstrated that the effect of gamma tACS over the M1 and the cerebellar hemisphere has phase specificity. This result suggests that intercortical functional synchronization is involved in the improvement of motor performance during gamma tACS over the M1 and the cerebellar hemisphere.