High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter
High-speed intravascular spectroscopic photoacoustic imaging at 1000 A-lines per second with a 0.9-mm diameter catheter
复制标题
使用直径 0.9 毫米的导管以每秒 1000 个 A 线的速度进行高速血管内光谱光声成像
DOI：
10.1117/1.jbo.20.6.065006
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发表时间：
2015-06-01
影响因子：
3.5
通讯作者：
Song, Liang
中科院分区：
文献类型：
--
作者：
Li, Yan;Gong, Xiaojing;Song, Liang
血管内光谱光声技术能够以高灵敏度和特异性成像动脉粥样硬化斑块组成，这对于识别易损斑块至关重要。在这里，我们设计并制造了一种直径为0.9 mm的导管，用于血管内光声（IVPA）成像，小于临床翻译所需的1 mm的临界尺寸。此外，研究人员还为导管开发了一种准聚焦光声激励方案，利用低至30 μ J/脉冲的激光能量，从支架和脂质中产生易于检测的IVPA信号。因此，本设计能够使用低能量，高重复率，ns脉冲光学参量振荡器激光器在1.2 μ m和1.7 μ m光谱波段进行高速光谱IVPA成像，用于脂质检测。具体来说，对于每个波长，实现了1 khz的IVPA a线速率，比以前报道的IVPA系统快100倍，提供类似的波长调谐范围。使用该系统，光谱IVPA成像的外膜周围脂肪组织从猪主动脉段被证明。成像速度的显著提高，以及导管尺寸的缩小和多波长光谱成像能力的提高，表明所开发的高速IVPA技术具有进一步转化为体内应用的巨大潜力。（三）2015年中国光学仪器工程师学会
Intravascular spectroscopic photoacoustic technology can image atherosclerotic plaque composition with high sensitivity and specificity, which is critical for identifying vulnerable plaques. Here, we designed and engineered a catheter of 0.9 mm in diameter for intravascular photoacoustic (IVPA) imaging, smaller than the critical size of 1 mm required for clinical translation. Further, a quasifocusing photoacoustic excitation scheme was developed for the catheter, producing well-detectable IVPA signals from stents and lipids with a laser energy as low as similar to 30 mu J/pulse. As a result, this design enabled the use of a low-energy, high-repetition rate, ns-pulsed optical parametric oscillator laser for high-speed spectroscopic IVPA imaging at both the 1.2-mu m and 1.7-mu m spectral bands for lipid detection. Specifically, for each wavelength, a 1-kHz IVPA A-line rate was achieved, similar to 100-fold faster than previously reported IVPA systems offering a similar wavelength tuning range. Using the system, spectroscopic IVPA imaging of peri-adventitial adipose tissue from a porcine aorta segment was demonstrated. The significantly improved imaging speed, together with the reduced catheter size and multi-wavelength spectroscopic imaging ability, suggests that the developed high-speed IVPA technology is of great potential to be further translated for in vivo applications. (C) 2015 Society of Photo-Optical Instrumentation Engineers (SPIE)