The lymph node at a glance - how spatial organization optimizes the immune response
The lymph node at a glance - how spatial organization optimizes the immune response
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DOI：
10.1242/jcs.241828
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发表时间：
2020-03-01
影响因子：
4
通讯作者：
Radtke, Andrea J.
中科院分区：
文献类型：
--
作者：
Grant, Spencer M.;Lou, Meng;Radtke, Andrea J.
哺乳动物免疫系统的一个标志是它能够有效地对外来抗原作出反应，而不会引起对自身抗原的不适当反应。此外，强大的免疫应答需要宿主内以低频率存在的各种细胞的协调。通过在淋巴结（LN）中浓缩抗原、抗原呈递细胞和抗原应答细胞，部分地解决了该问题。除了在一个位置容纳这些细胞类型之外，LN是由预先定位在明确定义的显微解剖学小生境内的细胞组成的高度组织化的结构。在这篇Cell Science at a Glance文章和随附的海报中，我们概述了LN微环境的关键细胞群体和组分，这些细胞群体和组分以稳定状态存在，并记录了免疫应答后这些元素的动态变化。这篇综述强调了LN作为先天性和适应性免疫反应的舞台，同时提供了一个优雅的例子，结构如何通知功能。
A hallmark of the mammalian immune system is its ability to respond efficiently to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore, a robust immune response requires the coordination of a diverse range of cells present at low frequencies within the host. This problem is solved, in part, by concentrating antigens, antigen-presenting cells and antigen-responsive cells in lymph nodes (LNs). Beyond housing these cell types in one location, LNs are highly organized structures consisting of pre-positioned cells within well-defined microanatomical niches. In this Cell Science at a Glance article and accompanying poster, we outline the key cellular populations and components of the LN microenvironment that are present at steady state and chronicle the dynamic changes in these elements following an immune response. This review highlights the LN as a staging ground for both innate and adaptive immune responses, while providing an elegant example of how structure informs function.