Multiple, objectively measured sleep dimensions including hypoxic burden and chronic kidney disease: findings from the Multi-Ethnic Study of Atherosclerosis
Multiple, objectively measured sleep dimensions including hypoxic burden and chronic kidney disease: findings from the Multi-Ethnic Study of Atherosclerosis
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DOI：
10.1136/thoraxjnl-2020-216422
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发表时间：
2021-07-01
期刊：
影响因子：
10
通讯作者：
Falchi, Mario
中科院分区：
文献类型：
--
作者：
Hopkinson, Nicholas S.;Rossi, Niccolo;Falchi, Mario
背景睡眠不良可能通过几个途径导致慢性肾脏疾病(CKD)，包括缺氧引起的全身和肾小球内压力、炎症、氧化应激和内皮功能障碍。然而，很少有研究调查多个客观测量的睡眠维度与CKD之间的关系。方法我们调查了1895名动脉粥样硬化睡眠辅助研究的多种族研究参与者的睡眠维度与慢性肾脏病的横断面相关性，这些参与者完成了家庭多导睡眠图、手腕活动记录仪和睡眠问卷。使用具有稳健方差的泊松回归模型，我们根据多个睡眠维度(包括非常短的(
Background Poor sleep may contribute to chronic kidney disease (CKD) through several pathways, including hypoxia-induced systemic and intraglomerular pressure, inflammation, oxidative stress and endothelial dysfunction. However, few studies have investigated the association between multiple objectively measured sleep dimensions and CKD. Methods We investigated the cross-sectional association between sleep dimensions and CKD among 1895 Multi-Ethnic Study of Atherosclerosis Sleep Ancillary Study participants who completed in-home polysomnography, wrist actigraphy and a sleep questionnaire. Using Poisson regression models with robust variance, we estimated separate prevalence ratios (PR) and 95% CIs for moderate-to-severe CKD (glomerular filtration rate 30 mg/g) among participants according to multiple sleep dimensions, including very short (