Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness.
Killing Me Unsoftly: Causes and Mechanisms of Arterial Stiffness.
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DOI：
10.1161/atvbaha.116.308563
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发表时间：
2017-02
期刊：
影响因子：
--
通讯作者：
Raaz U
中科院分区：
文献类型：
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作者：
Lyle AN;Raaz U
主动脉是一种血管，为从心脏流向周围器官和组织的血流提供低阻力路径。然而，主动脉具有另一个中心血液动力学功能，主动脉壁的弹性性质提供了显着的生物力学缓冲能力，补充了脉动心脏血流，这通常被称为 Windkessel 功能。动脉壁硬化导致中枢血流动力学发生根本性改变，对器官功能产生广泛的有害影响。在这篇综述文章中，我们旨在简要概述一些导致动脉僵硬增加的最常见机制、动脉僵硬的后果以及发生动脉僵硬的临床状况，重点介绍该领域的最新进展。
The aorta is a blood vessel that provides a low resistance path for blood flow directed from the heart to peripheral organs and tissues. However, the aorta has another central hemodynamic function whereby the elastic nature of the aortic wall provides a significant biomechanical buffering capacity complementing the pulsatile cardiac blood flow and this is often referred to as Windkessel function. Stiffening of the arterial wall leads to fundamental alterations in central hemodynamics with widespread detrimental implications for organ function. In this review article, we aim to provide a short general overview of some of the most common mechanisms that contribute to increased arterial stiffness, the consequences of arterial stiffening, and the clinical conditions in which arterial stiffness occurs with a focus on recent advancements in the field.