In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis.
In vivo spike-timing-dependent plasticity in the optic tectum of Xenopus laevis.
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DOI：
10.3389/fnsyn.2010.00007
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发表时间：
2010-01-01
影响因子：
3.7
通讯作者：
Akerman, Colin J
中科院分区：
文献类型：
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作者：
Richards, Blake A;Aizenman, Carlos D;Akerman, Colin J
尖峰时间依赖性可塑性（STDP）在体内被发现在各种系统和物种，但在体内STDP的第一个演示进行了视顶盖的非洲爪蟾胚胎。从那时起，视顶盖就成为研究感觉系统中STDP的一个很好的实验模型，使研究人员能够在早期发育过程中探索这种形式的突触可塑性的发育后果。在这篇综述中，我们将描述什么是已知的作用，STDP在塑造前馈和经常性的电路在视顶盖与视觉功能的影响为重点。我们将讨论视顶盖和哺乳动物的感觉系统，是相关的STDP之间的相似性和差异。最后，我们将强调胚胎顶盖的独特性质，使其成为一个重要的系统，研究人员谁感兴趣的STDP如何有助于活动依赖性发展的感觉计算。
Spike-timing-dependent plasticity (STDP) is found in vivo in a variety of systems and species, but the first demonstrations of in vivo STDP were carried out in the optic tectum of Xenopus laevis embryos. Since then, the optic tectum has served as an excellent experimental model for studying STDP in sensory systems, allowing researchers to probe the developmental consequences of this form of synaptic plasticity during early development. In this review, we will describe what is known about the role of STDP in shaping feed-forward and recurrent circuits in the optic tectum with a focus on the functional implications for vision. We will discuss both the similarities and differences between the optic tectum and mammalian sensory systems that are relevant to STDP. Finally, we will highlight the unique properties of the embryonic tectum that make it an important system for researchers who are interested in how STDP contributes to activity-dependent development of sensory computations.