In Vivo ESR Study on Hepatic Reduction of a Nitroxide Radical after Administration of Glucose in Rats
In Vivo ESR Study on Hepatic Reduction of a Nitroxide Radical after Administration of Glucose in Rats
复制标题
大鼠给予葡萄糖后氮氧自由基肝脏还原的体内 ESR 研究
DOI：
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发表时间：
2001
期刊：
影响因子：
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通讯作者：
H. Kamada
中科院分区：
文献类型：
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作者：
M. Tada;H. Yokoyama;Y. Toyoda;H. Ohya;T. Ogata;H. Kamada
The in vivo reducing ability of a nitroxide radical, 4‐hydroxyl‐2,2,6,6‐tetramethylpiperidin‐1‐oxyl (TEMPOL), in the liver of rats was estimated by using an electron spin resonance spectrometer equipped with a surface‐coil‐type resonator following administration of glucose. Both oral and intravenous administration of glucose significantly enhanced the reduction capacity. In vitro studies show that the reduction site of TEMPOL in the hepatic homogenate is located in the mitochondrial respiratory chain and microsomal electron transport system. These findings indicate that the enhancement of activity of these systems caused by the glucose administration prompts reduction of TEMPOL in the liver.
DOI：
10.1016/0304-4165(90)90053-y
发表时间：
1990-06-20
期刊：
BIOCHIMICA ET BIOPHYSICA ACTA
影响因子：
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作者：
IANNONE, A;TOMASI, A;SWARTZ, HM
通讯作者：
SWARTZ, HM