Allografts surviving for 26 to 29 years following living-related kidney transplantation: analysis by light microscopy, in situ hybridization for the Y chromosome, and anti-HLA antibodies.
Allografts surviving for 26 to 29 years following living-related kidney transplantation: analysis by light microscopy, in situ hybridization for the Y chromosome, and anti-HLA antibodies.
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活体肾移植后同种异体移植物存活 26 至 29 年：光学显微镜分析、Y 染色体原位杂交和抗 HLA 抗体。
DOI：
10.1016/s0272-6386(12)80162-4
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Demetris,J
中科院分区：
文献类型：
--
作者：
Randhawa,PS;Starzl,T;Ramos,HC;Nalesnik,MA;Demetris,J
我们研究了7例年龄在14至40岁之间接受活体肾移植的患者，他们的同种异体移植存活时间为26至29年。血尿素和肌酐要么在正常范围内，要么轻微升高。组织病理学检查仅显示轻度系膜扩张、间质纤维化和动脉硬化。抗hla抗体免疫过氧化物酶染色或用Y染色体探针原位杂交显示移植物内供体小管上皮和血管内皮的持久性。一例可见受体源性肾小球细胞，所有病例均可见间质淋巴细胞浸润。对这些病例的临床病理资料的回顾表明，中枢和外周免疫机制都有助于维持移植物的长期存活。这种延长的存活不依赖于六种抗原匹配、供体HLA抗原表达的下调以及宿主上皮/内皮向同种异体移植物的长入。
We studied seven patients aged 14 to 40 years who received living-related kidney transplants and had allograft survivals of 26 to 29 years. The blood urea and creatinine were either within normal limits or marginally elevated. Histopathologic examination showed only mild mesangial expansion, interstitial fibrosis, and arteriosclerosis. Immunoperoxidase staining with anti-HLA antibodies or in situ hybridization with a Y chromosome probe showed persistence of donor tubular epithelium and vascular endothelium within the graft. Recipient-derived glomerular cells were seen in one case, and interstitial lymphocytic infiltrates were seen in all cases. A review of the clinicopathologic data available for these cases indicated that both central and peripheral immunologic mechanisms contributed to the maintenance of prolonged graft survival. This extended survival was independent of six antigen matching, downregulation of donor HLA antigen expression, and ingrowth of host epithelium/endothelium into the allograft.