Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer.
Using mice to treat (wo)men: mining genetic changes in patient xenografts to attack breast cancer.
复制标题
使用小鼠治疗男性(女性):挖掘患者异种移植物中的基因变化来攻击乳腺癌。
DOI:
10.1016/j.celrep.2013.09.008
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发表时间:
2013
期刊:
影响因子:
8.8
通讯作者:
Davidson,NancyE
中科院分区:
文献类型:
--
作者:
Oesterreich,Steffi;Brufsky,AdamM;Davidson,NancyE
In this issue ofCell Reports, Li et al. show that the analysis of genetic changes in patient-derived xenografts can reveal crucial details of tumor evolution, such as the emergence of functional estrogen receptor mutations in endocrine-resistant breast cancer.