Ultraviolet radiation and autoimmune disease: insights from epidemiological research
Ultraviolet radiation and autoimmune disease: insights from epidemiological research
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DOI：
10.1016/s0300-483x(02)00257-3
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发表时间：
2002-12-27
期刊：
影响因子：
4.5
通讯作者：
van der Mei, I
中科院分区：
文献类型：
--
作者：
Ponsoby, AL;McMichael, A;van der Mei, I
本文综述了流行病学证据表明，紫外线辐射（LTVR）可能发挥保护作用的三种自身免疫性疾病：多发性硬化症，胰岛素依赖型糖尿病和类风湿性关节炎。迄今为止，大部分信息都是从人口研究中积累的，这些研究研究了地理或气候与自身免疫性疾病患病率之间的关系。在这三种疾病中，至少有两种疾病的流行率随着纬度的增加而出现有趣的梯度。这在多发性硬化症中最为明显，但在欧洲和北美的胰岛素依赖型糖尿病中也显示出类似的梯度。季节性因素对疾病发病率和临床病程的影响，以及最近在个体水平上的分析研究，为LTVR在其中一些疾病中可能的保护作用提供了进一步的支持，但数据并不确定。器官特异性自身免疫性疾病涉及Th 1细胞介导的免疫过程。最近在光免疫学方面的研究表明，紫外线B（UVB）可以通过我们讨论的几种机制特异性地减弱这些过程。特别是，可能的贡献紫外线诱导的血清维生素D（1，25（OH）（2）D-3）水平的增加，在这些疾病的有益的免疫调节进行了讨论。(C)2002爱思唯尔科学爱尔兰有限公司保留所有权利。
This review examines the epidemiological evidence that suggests ultraviolet radiation (LTVR) may play a protective role in three autoimmune diseases: multiple sclerosis, insulin-dependent diabetes mellitus and rheumatoid arthritis. To date, most of the information has accumulated from population studies that have studied the relationship between geography or climate and autoimmune disease prevalence. An interesting gradient of increasing prevalence with increasing latitude has been observed for at least two of the three diseases. This is most evident for multiple sclerosis, but a similar gradient has been shown for insulin-dependent diabetes mellitus in Europe and North America. Seasonal influences on both disease incidence and clinical course and, more recently, analytical studies at the individual level have provided further support for a possible protective role for LTVR in some of these diseases but the data are not conclusive. Organ-specific autoimmune diseases involve Th1 cell-mediated immune processes. Recent work in photoimmunology has shown ultraviolet B (UVB) can specifically attenuate these processes through several mechanisms which we discuss. In particular, the possible contribution of an UVR-induced increase in serum vitamin D (1,25(OH)(2)D-3) levels in the beneficial immunomodulation of these diseases is discussed. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.