The Role of Non-Coding RNAs and Isothiocyanates in Cancer.
The Role of Non-Coding RNAs and Isothiocyanates in Cancer.
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DOI：
10.1002/mnfr.201700913
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发表时间：
2018-09
影响因子：
5.2
通讯作者：
Tollefsbol TO
中科院分区：
文献类型：
--
作者：
Martin SL;Royston KJ;Tollefsbol TO
癌症是美国第二大死亡原因，仅次于心脏病。目前的癌症治疗包括化疗、手术和/或放疗。由于目前的癌症治疗方法往往具有苛刻的效果，研究人员正在将他们的努力集中在膳食植物化学物质介导的癌症预防上。自从发现癌症可以通过遗传和表观遗传途径引发和发展以来，关于营养化合物介导的表观遗传效应的研究大幅增加。异硫氰酸酯是一种存在于十字花科蔬菜中的天然分子，具有多种抗癌活性。虽然异硫氰酸酯已被广泛记录为表观遗传过程（如DNA甲基化和组蛋白修饰）的关键参与者，但它们对非编码RNA的影响尚未得到充分研究。非编码RNA是靶向mRNA产生并抑制蛋白质翻译的分子，并且已知在各种人类恶性肿瘤中失调。研究已经使用非编码RNA作为探索癌症治疗的新靶点。本文综述了异硫氰酸酯及其对非编码RNA在癌症预防和治疗中的作用。
Cancer is the second leading cause of mortalities in the United States, only exceeded by heart disease. Current cancer treatments include chemotherapy, surgery and/or radiation. Due to the often harsh effects of current cancer therapies, investigators are focusing their efforts on cancer prevention mediated by dietary phytochemicals. Since the discovery that cancer can be initiated by and progress through both genetic and epigenetic pathways, there has been a significant surge in studies on epigenetic effects mediated by nutritive compounds. Isothiocyanates, naturally occurring molecules found in cruciferous vegetables, have been documented to exhibit many anticarcinogenic activities. Although isothiocyanates have been extensively documented as key players in epigenetic processes such as DNA methylation and histone modifications, their effects on non-coding RNAs is understudied. Non-coding RNAs are molecules that target mRNA production and repress protein translation and are known to be dysregulated in various human malignancies. Studies have used non-coding RNAs as novel targets for exploration in cancer therapy. This review focuses on the exploration of isothiocyanates and their effect on non-coding RNAs in cancer prevention and therapy.
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影响因子：
5.2
作者：
Appari M;Babu KR;Kaczorowski A;Gross W;Herr I
通讯作者：
Herr I
DOI：
10.1016/j.jnutbio.2017.01.001
发表时间：
2017-04
期刊：
The Journal of nutritional biochemistry
影响因子：
--
作者：
Beaver LM;Kuintzle R;Buchanan A;Wiley MW;Glasser ST;Wong CP;Johnson GS;Chang JH;Löhr CV;Williams DE;Dashwood RH;Hendrix DA;Ho E
通讯作者：
Ho E
DOI：
10.1016/j.omtn.2017.06.005
发表时间：
2017-09-15
期刊：
Molecular therapy. Nucleic acids
影响因子：
--
作者：
Chakraborty C;Sharma AR;Sharma G;Doss CGP;Lee SS
通讯作者：
Lee SS
影响因子：
4.7
作者：
Bhattacharya, Arup;Li, Yun;Zhang, Yuesheng
通讯作者：
Zhang, Yuesheng
影响因子：
--
作者：
Basu, Aruna;Alder, Hansjuerg;Haldar, Subrata
通讯作者：
Haldar, Subrata