Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction
Effects of canrenoate plus angiotensin-converting enzyme inhibitors versus angiotensin-converting enzyme inhibitors alone on systolic and diastolic function in patients with acute anterior myocardial infarction
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DOI：
10.1016/j.ahj.2005.03.032
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发表时间：
2005-11-01
影响因子：
4.8
通讯作者：
Paterna, S
中科院分区：
文献类型：
--
作者：
Di Pasquale, P;Cannizzaro, S;Paterna, S
背景醛固酮（ALDO）通过心血管组织中的盐皮质激素受体发挥促纤维化作用。方法采用随机双盲对照研究方法，对510例急性前壁心肌梗死（MI）患者给予坎利酸酯（25 mg/d）联合卡托普利治疗，并与单纯卡托普利治疗进行比较。治疗10天后观察到血清肌酐浓度2.0 mg/L。在180天时，与接受安慰剂的患者相比，接受坎利酸盐治疗的患者二尖瓣E波-A波比率较高（P =.0001），左心室收缩末期容积较小（P = .0001）。没有进一步的副作用，观察在studyperiod.Conclusions我们的数据表明，卡托普利加canrenoate的组合是耐受性良好的急性心肌梗死后，对收缩和舒张参数有有益的影响，并可能减少心肌梗死后重塑。
Background Aldosterone (ALDO) exerts profibrotic effects, acting via the mineralocorticoid receptors in cardiovascular tissues. Aldosterone antagonism in combination with angiotensin-converting enzyme inhibition may better protect against the untoward effects of ALDO than angiotensin-converting enzyme inhibition alone.Methods in a double-blind randomized study, the tolerability and efficacy of canrenoate (25 mg/d) plus captopril versus captopril alone were evaluated in 510 patients with an acute anterior myocardial infarction (MI), a serum creatinine concentration 2.0 mg/L after 10 days of treatment were observed. At 180 days, the mitral E-wave-A-wave ratio was higher (P = .0001) and left ventricular end-systolic volume was smaller (P = .0001) in patients treated with canrenoate than in those receiving placebo. No further side effects were observed during the study period.Conclusions Our data suggest that the combination of captopril plus canrenoate is well tolerated after an acute MI and has beneficial effect on systolic and diastolic parameters and may decrease post-MI remodeling.