Frequency distribution analysis of the normal lymphocyte response to phytohemagglutinin.
Frequency distribution analysis of the normal lymphocyte response to phytohemagglutinin.
复制标题
正常淋巴细胞对植物血凝素反应的频率分布分析。
DOI：
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发表时间：
1974
期刊：
影响因子：
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通讯作者：
H. Allen
中科院分区：
文献类型：
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作者：
H. Allen
本文用植物血凝素（PHA）诱导的淋巴细胞胚细胞生成作为体外检测循环胸腺依赖性（T）淋巴细胞免疫活性的方法。从一组正常个体中积累的数据显示了广泛的反应，并在此列出。响应变异性是在高PHA浓度下个体内时间依赖性变化的函数。在低PHA浓度下，个体内响应随时间的变化较大，个体间平均响应的变化也较大。在低PHA浓度下也获得了响应的非高斯频率分布。观察到的反应的频率分布似乎并不强烈依赖于正常人的年龄分布。
Phytohemagglutinin (PHA)-induced lymphocyte blastogenesls was used as an in vitro test for the immunocompetence of circulating thymus-dependent (T) lymphocytes. The data accumulated from a pool of normal individuals showed a wide range of responses and are presented here. The response variability is a function of time-dependent variations within individuals at high PHA concentrations. At low PHA concentrations, there is large variability of response within individuals as a function of time as well as large variability in mean responses between individuals. A non-Gaussian frequency distribution of responses is also obtained at low PHA concentration. The frequency distribution of responses observed does not appear to be strongly dependent upon the age distribution of the normals.