Controlling invasive rodents via synthetic gene drive and the role of polyandry.
Controlling invasive rodents via synthetic gene drive and the role of polyandry.
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通过合成基因驱动和一妻多夫的作用控制入侵啮齿动物。
DOI：
10.1098/rspb.2019.0852
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发表时间：
2019
期刊：
影响因子：
--
通讯作者：
Manser A
中科院分区：
文献类型：
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作者：
Manser A
家鼠是一种主要的生态系统害虫，特别是威胁岛屿生态系统作为一个非本地入侵物种。合成生物学的快速发展为生物多样性保护提供了新的途径。最近，一种合成的精子杀伤基因驱动构建体被称为Sry，已被提出作为一种手段，以消除目标小鼠种群，由于缺乏女性。一妻多夫制是一个在围绕这种驱动器应用的讨论中很少受到关注的因素。先前的研究已经证明，杀精司机对男性精子的竞争能力有极大的损害。在这里，我们研究的重要性，这种影响的理论模型上的Thet-Sry系统。我们发现，一妻多夫制大大阻碍了Sry的传播，因此要成功根除，释放工作必须增加三到六倍。我们讨论了我们的发现潜在的害虫控制方案的影响，驱动器传播超出目标人群的风险，以及驱动器阻力的出现。我们的工作强调，在自然环境中确定驱动动力学的力量的坚实理解是成功的驱动应用的关键，探索基因驱动的自然多样性可能会为有效的基因驱动设计提供信息。
House mice are a major ecosystem pest, particularly threatening island ecosystems as a non-native invasive species. Rapid advances in synthetic biology offer new avenues to control pest species for biodiversity conservation. Recently, a synthetic sperm-killing gene drive construct calledt-Sryhas been proposed as a means to eradicate target mouse populations owing to a lack of females. A factor that has received little attention in the discussion surrounding such drive applications is polyandry. Previous research has demonstrated that sperm-killing drivers are extremely damaging to a male’s sperm competitive ability. Here, we examine the importance of this effect on thet-Srysystem using a theoretical model. We find that polyandry substantially hampers the spread oft-Srysuch that release efforts have to be increased three- to sixfold for successful eradication. We discuss the implications of our finding for potential pest control programmes, the risk of drive spread beyond the target population, and the emergence of drive resistance. Our work highlights that a solid understanding of the forces that determine drive dynamics in a natural setting is key for successful drive application, and that exploring the natural diversity of gene drives may inform effective gene drive design.