Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.
Mitochondrial reactive oxygen species regulate cellular signaling and dictate biological outcomes.
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DOI：
10.1016/j.tibs.2010.04.002
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发表时间：
2010-09
影响因子：
13.8
通讯作者：
Chandel, Navdeep S.
中科院分区：
文献类型：
--
作者：
Hamanaka, Robert B.;Chandel, Navdeep S.
活性氧（ROS）历来被视为有毒代谢副产物和多种人类病理的致病因子。然而，最近的研究表明，ROS 是细胞信号传导途径的关键中间体。尽管很明显，专门的细胞 ROS 产生者（例如 NADPH 氧化酶）参与信号传导，但有证据表明，线粒体产生 ROS 也是一个严格控制的过程，并在维持细胞氧化稳态和细胞信号传导途径的传播中发挥作用。因此，线粒体中 ROS 的产生整合了细胞能量状态、代谢物浓度和其他上游信号传导事件，并对细胞应激信号传导、干细胞群的维持、细胞存活和致癌转化具有重要意义。
Reactive oxygen species (ROS) have historically been viewed as toxic metabolic byproducts and causal agents in a myriad of human pathologies. More recent work, however, indicates that ROS are critical intermediates of cellular signaling pathways. Although it is clear that dedicated cellular ROS producers such as NADPH oxidases participate in signaling, evidence suggests that mitochondrial production of ROS is also a tightly controlled process, and plays a role in the maintenance of cellular oxidative homeostasis and propagation of cellular signaling pathways. Production of ROS at mitochondria thus integrates cellular energy state, metabolite concentrations, and other upstream signaling events and has important implications in cellular stress signaling, maintenance of stem cell populations, cellular survival, and oncogenic transformation.
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