New phenylpropanoid allopyranosides from the rhizomes of Cimicifuga dahurica
New phenylpropanoid allopyranosides from the rhizomes of Cimicifuga dahurica
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升麻根茎中的新苯丙素别吡喃苷
DOI：
10.1016/j.bmcl.2019.05.011
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发表时间：
2019
影响因子：
2.7
通讯作者：
Yu Yang
中科院分区：
文献类型：
--
作者：
Lu Qing;Li Hai-bo;Pang Qian-qian;Zhang Wei-yang;Su Zhen-zhen;Pan Da-bo;Yao Xin-Sheng;Yu Yang
从茜草根状茎中分离得到5个新的苯丙类异丙苷（1-5）和5个已知化合物（6-10）。通过光谱分析、化学分析和文献比较，确定了它们的结构。对所有分离株进行抗炎活性评价。化合物6、9和10对LPS刺激的RAW 264.7巨噬细胞产生pge2有抑制作用，ic50值分别为19.72、6.33和39.90 µM。
Five new phenylpropanoid allopyranosides (1–5), along with five known compounds (6–10) were isolated from the rhizomes of Cimicifugadahurica. Their structures were established by means of spectroscopic analyses and chemical methods, as well as comparison with literatures. The anti-inflammatory activities of all isolates were evaluated. Compounds6,9and10exhibited inhibitory effects on PGE2production in LPS stimulated RAW 264.7 macrophages with IC50values of 19.72, 6.33 and 39.90 µM, respectively.