ARE LIMB DEVELOPMENT AND LIMB REGENERATION BOTH INITIATED BY AN INTEGUMENTARY WOUNDING - A HYPOTHESIS
ARE LIMB DEVELOPMENT AND LIMB REGENERATION BOTH INITIATED BY AN INTEGUMENTARY WOUNDING - A HYPOTHESIS
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DOI：
10.1111/j.1432-0436.1984.tb00270.x
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发表时间：
1984-01-01
期刊：
影响因子：
2.9
通讯作者：
BORGENS, RB
中科院分区：
文献类型：
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作者：
BORGENS, RB
虽然蝾螈肢体的实际伤口可能会启动肢体再生，但局部和发育程序化的表皮伤口可能会启动肢体发育。这些皮肤损伤引起的电生理变化可能是肢体再生和肢体发育的共同点。这种早期电事件被认为可以启动或引导细胞的早期积累，并帮助产生肢体出现的局部环境。该方案提供了一种自限性正反馈机制，用于产生局部区域，其中其他发育机制与内源性电场（或完全不存在）协同作用，从而导致肢体分化。这一假说可能并不局限于肢体的形成;它可能具有更普遍的意义，即，在胚胎器官形成的过程中。通过这样的机制，和发展基板（即，听觉或嗅觉基板）可能形成并定位。
Whereas an actual wound to a salamander limb may initiate limb regeneration, a local and developmentally programmed integumentary wound may initiate limb development. The electrophysiological changes induced by these lesions of the skin maybe a common denominator linking limb regeneration and limb development. Such early electrical events are considered to initiate or guide the early accumulation of cells, and to help to produce the local environment in which a limb will arise. This scheme provides a self-limiting positive-feedback mechanism for the production of a localized area where other developmental mechanisms act in concert with endogenous electrical fields (or in their complete absence), thereby leading to limb differentiation. This hypothesis may not be restricted to limb formation; it may be of more general significance, i.e., in the process of organogenesis in embryos. By such a mechanism, and developing placode (i.e., auditory or olfactory placodes) might form and localize.