A reciprocal relationship between cutaneous nerves and repairing skin wounds in the developing chick embryo
A reciprocal relationship between cutaneous nerves and repairing skin wounds in the developing chick embryo
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DOI：
10.1006/dbio.2001.0395
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发表时间：
2001-10-01
影响因子：
2.7
通讯作者：
Martin, P
中科院分区：
文献类型：
--
作者：
Harsum, S;Clarke, JDW;Martin, P
各种研究表明，成人皮肤愈合的速度可能在某种程度上取决于皮肤神经发出的信号。此外，成人伤口似乎在愈合过程中被感觉神经过度支配。为了进一步研究这种相互关系，我们使用了一个简单的胚胎模型来观察伤口对神经的影响，反过来，神经对伤口的影响。我们发现，在正常神经支配之前（E4），或在皮肤神经支配正常建立后不久（E7），雏鸡翅芽背部的伤口会通过扰乱发育指导线索微妙地改变分支模式，但不会引起神经支配过度，而E14的伤口确实会引起神经支配过度。通过创造无神经翅膀的小鸡，我们发现从E7开始，在没有神经的情况下伤口愈合明显受损。这些观察结果表明，从皮肤神经支配的最早阶段开始，神经的存在有利于愈合过程，但与新生儿和成人组织相反，胚胎和早期胎儿的伤口愈合不会引发神经支配过度。(C) 2001学术出版社。
Various studies have suggested that the rate of adult skin healing may be in some way dependent on signals emanating from cutaneous nerves. Further, it appears that adult wounds become hyperinnervated by sensory nerves during the process of healing. in order to investigate this reciprocal relationship further, we have used a simple embryonic model to look at the effect of wounds on nerves, and conversely, the effect of nerves on wounds. We find that wounds made to the dorsum of the chick wing bud, at a stage prior to normal innervation (at E4), or soon after the normal establishment of cutaneous innervation (at E7), subtly alter the pattern of branching by perturbing developmental guidance cues, but do not cause hyperinnervation, whereas wounding at E14 does cause hyperinnervation. By creating chicks with nerveless wings, we show that from E7, wound healing in the absence of nerves is significantly impaired. These observations suggest that, from the earliest stages of skin innervation, the presence of nerves is beneficial to the healing process, but that, in contrast to neonatal and adult tissues, wound healing in the embryo and early foetus does not trigger hyperinnervation. (C) 2001 Academic Press.