Origin and evolution of gene for prolactin-induced protein
Origin and evolution of gene for prolactin-induced protein
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DOI：
10.1016/j.gene.2006.07.014
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发表时间：
2006-11-15
期刊：
影响因子：
3.5
通讯作者：
Osawa, Motoki
中科院分区：
文献类型：
--
作者：
Kitano, Takashi;Tian, Wei;Osawa, Motoki
催乳素诱导蛋白（PIP）是一种分泌到几个腺体的液体中的小蛋白。我们确定了5个类人猿的PIP编码序列，并估计了哺乳动物PIP基因树每个分支的同义和非同义替换的数量。连接类人猿和旧大陆猴的分支显示出显著高于同义替换的非同义替换。这些变化往往是积累在纤连蛋白结合域。许多其他灵长类分支也显示出更高的非同义取代比同义取代，从而表明灵长类的PIP基因经历了某种正选择。我们还考虑了PIP基因与α-2-巨球蛋白基因家族的系统发育关系。结果表明，PIP基因是在两栖动物与其他四足动物分化后，从α-2-巨球蛋白基因家族的一个成员通过部分基因复制而产生的。(c)2006 Elsevier B. V.保留所有权利。
Prolactin-induced protein (PIP) is a small protein secreted into the fluid in several glands. We determined the PIP coding sequences of 5 hominoid species and estimated the numbers of synonymous and nonsynonymous substitutions for each branch of the mammalian PIP gene tree. The branch connecting hominoids and Old World monkeys showed significantly higher nonsynonymous than synonymous substitutions. These changes tended to be accumulated in the fibronectin-binding domain. Many other primate branches also showed higher nonsynonymous than synonymous substitutions, thus suggesting that the PIP genes of primates have experienced some kind of positive selection. We also considered the phylogenetic relationship of the PIP gene with the alpha-2-macroglobulin gene family. The results indicate that the PIP gene arose by partial gene duplication from a member of the alpha-2-macroglobulin gene family after the divergence between amphibians and other tetrapods. (c) 2006 Elsevier B.V. All rights reserved.