The platelet‐activating receptor C‐type lectin receptor‐2 plays an essential role in liver regeneration after partial hepatectomy in mice
The platelet‐activating receptor C‐type lectin receptor‐2 plays an essential role in liver regeneration after partial hepatectomy in mice
复制标题
DOI：
10.1111/jth.13672
复制
发表时间：
2017-05
影响因子：
10.4
通讯作者：
H. Kono;H. Fujii;K. Suzuki-Inoue;O. Inoue;S. Furuya;K. Hirayama;Yoshihiro Akazawa;Yuuki Nakata;Chao Sun;N. Tsukiji;Toshiaki Shirai;Y. Ozaki
中科院分区：
文献类型：
--
作者：
H. Kono;H. Fujii;K. Suzuki-Inoue;O. Inoue;S. Furuya;K. Hirayama;Yoshihiro Akazawa;Yuuki Nakata;Chao Sun;N. Tsukiji;Toshiaki Shirai;Y. Ozaki
探讨C型凝集素受体-2(CLEC-2)在70%肝切除(HPx)后的再生作用。对从嵌合小鼠(FlKO)的血小板中缺失的野生型或CLEC-2进行HPx。FlKO的肝脏/体重比显著低于野生型。CLEC-2在HPx后肝再生中起重要作用。
Essentials Regeneration role of C‐type lectin receptor‐2 (CLEC‐2) after 70% hepatectomy (HPx) was investigated. Wild‐type or CLEC‐2 deleted from platelets of chimeric mice (flKO) underwent HPx. The liver/body weight ratio was significantly lower in the flKO than in the wild‐type. CLEC‐2 plays an essential role in liver regeneration after HPx.